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Rabbit Polyclonal Acetyl-Cytokeratin-pan (K194) antibody (STJ90157)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cytokeratin-pan (Acetyl Lys194) Polyclonal Antibody.
Check alternative names for the antibodyExpand
KRT2 antibody, KRT2A antibody, KRT2E antibody,|CK 2e antibody|Cytokeratin-2e antibody|Epithelial keratin-2e antibody|K2e antibody|Keratin type II cytoskeletal 2 epidermal antibody|Keratin-2 epidermis antibody|KRT2 antibody|KRT2A antibody|KRT2E antibody|Type-II keratin Kb2 antibody|Anti-Cytokeratin 2e antibody [Ks2.342.7.1] (ab19122)
SCBT cat No: sc-58731|sc-49179|
Cytokeratin-pan (Acetyl Lys194) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Acetyl-Cytokeratin-pan (K194) Polyclonal Antibody detects endogenous levels of Cytokeratin protein only when acetylated at K194.
Synthesized acetyl-peptide derived from human Cytokeratin around the acetylation site of K194
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cytokeratin-pan (Acetyl Lys194) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cytokeratin-pan (Acetyl Lys194) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Keratin, type II cytoskeletal 2 epidermal antibody, Cytokeratin-2e antibody, CK-2e antibody, Epithelial keratin-2e antibody, Keratin-2 epidermis antibody, Keratin-2e antibody, K2e antibody, Type-II keratin Kb2 antibody
|Protein names|| |
Keratin, type II cytoskeletal 2 epidermal , Cytokeratin-2e , CK-2e , Epithelial keratin-2e , Keratin-2 epidermis , Keratin-2e , K2e , Type-II keratin Kb2
|Protein function|| |
Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization.
|Protein tissue specificity|| |
Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.
|Involvement in disease|| |
Ichthyosis bullosa of Siemens (IBS) [MIM:146800]: A rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis characterized by generalized erythema and extensive blistering from birth. Large, dark gray hyperkeratoses are observed in later weeks. The skin of IBS patients is unusually fragile and has a tendency to shed the outer layers of the epidermis, producing localized denuded areas (molting effect). IBS usually improves with age so that in most middle-aged patients the hyperkeratosis and keratotic lichenification is limited to the flexural folds of the major joints. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the intermediate filament family.
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St John’s Laboratory Ltd.
|Product type|| |
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