Rabbit Polyclonal Acetyl-HNF-3alpha/beta/gamma (K264/253/211) antibody (STJ90141)

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Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Acetyl-HNF-3alpha/beta/gamma (K264/253/211) antibody (STJ90141)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for HNF-3alpha/beta/gamma (Acetyl Lys264/253/211) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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FOXA1 antibody, HNF3A antibody, TCF3A antibody,|forkhead box A1 antibody|Forkhead box protein A1 antibody|FOX A1 antibody|FOXA1 antibody|FOXA1_HUMAN antibody|hepatocyte nuclear factor 3 alpha antibody|Hepatocyte nuclear factor 3-alpha antibody|HNF 3A antibody|HNF-3-alpha antibody|HNF-3A antibody|HNF3A antibody|MGC33105 antibody|TCF 3A antibody|TCF-3A antibody|TCF3A antibody|Transcription factor 3A antibody|Anti-FOXA1 antibody – ChIP Grade (ab23738)
SCBT cat No: sc-514695|sc-22841|sc-101058|sc-9186|sc-6553|

 

Name

HNF-3alpha/beta/gamma (Acetyl Lys264/253/211) Polyclonal Antibody

Catalogue No.

STJ90141

Reactivity

Human, Mouse, Rat

Specificity

Acetyl-HNF-3alpha/beta/gamma (K264/253/211) Polyclonal Antibody detects endogenous levels of HNF-3alpha/beta/gamma protein only when acetylated at K264/253/211.

Immunogen

Synthesized acetyl-peptide derived from the human HNF-3alpha/beta/gamma around the acetylation site of K264/253/211

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

49 kDa

Formulation

HNF-3alpha/beta/gamma (Acetyl Lys264/253/211) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

HNF-3alpha/beta/gamma (Acetyl Lys264/253/211) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Hepatocyte nuclear factor 3-alpha antibody, HNF-3-alpha antibody, HNF-3A antibody, Forkhead box protein A1 antibody, Transcription factor 3A antibody, TCF-3A antibody

Database links

Human UniProt/Swiss-Prot:P55317;Mouse UniPort/Swiss-Prot: P35582;Rat UniProt/Swiss-Port: P23512;Human Entrez Gene: 3169;Mouse Entrez Gene: 15375;Rat Entrez Gene: Rn.10470

Protein names

Hepatocyte nuclear factor 3-alpha , HNF-3-alpha , HNF-3A , Forkhead box protein A1 , Transcription factor 3A , TCF-3A

Protein function

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ‘pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5′-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3′ (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at ‘Lys-5’ (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.

Protein tissue specificity

Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.

Protein sequence and domain

Contains 1 fork-head DNA-binding domain.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>HNF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HNF-3alpha/beta/gamma (Acetyl Lys264/253/211) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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