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Rabbit Polyclonal Acetyl-HNF-3alpha/beta/gamma (K264/253/211) antibody (STJ90141)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for HNF-3alpha/beta/gamma (Acetyl Lys264/253/211) Polyclonal Antibody.
Check alternative names for the antibodyExpand
FOXA1 antibody, HNF3A antibody, TCF3A antibody,|forkhead box A1 antibody|Forkhead box protein A1 antibody|FOX A1 antibody|FOXA1 antibody|FOXA1_HUMAN antibody|hepatocyte nuclear factor 3 alpha antibody|Hepatocyte nuclear factor 3-alpha antibody|HNF 3A antibody|HNF-3-alpha antibody|HNF-3A antibody|HNF3A antibody|MGC33105 antibody|TCF 3A antibody|TCF-3A antibody|TCF3A antibody|Transcription factor 3A antibody|Anti-FOXA1 antibody – ChIP Grade (ab23738)
SCBT cat No: sc-514695|sc-22841|sc-101058|sc-9186|sc-6553|
HNF-3alpha/beta/gamma (Acetyl Lys264/253/211) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Acetyl-HNF-3alpha/beta/gamma (K264/253/211) Polyclonal Antibody detects endogenous levels of HNF-3alpha/beta/gamma protein only when acetylated at K264/253/211.
Synthesized acetyl-peptide derived from the human HNF-3alpha/beta/gamma around the acetylation site of K264/253/211
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
HNF-3alpha/beta/gamma (Acetyl Lys264/253/211) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
HNF-3alpha/beta/gamma (Acetyl Lys264/253/211) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Hepatocyte nuclear factor 3-alpha antibody, HNF-3-alpha antibody, HNF-3A antibody, Forkhead box protein A1 antibody, Transcription factor 3A antibody, TCF-3A antibody
|Protein names|| |
Hepatocyte nuclear factor 3-alpha , HNF-3-alpha , HNF-3A , Forkhead box protein A1 , Transcription factor 3A , TCF-3A
|Protein function|| |
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ‘pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5′-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3′ (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at ‘Lys-5’ (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
|Protein tissue specificity|| |
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
|Protein sequence and domain|| |
Contains 1 fork-head DNA-binding domain.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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