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Rabbit Polyclonal Acetyl-Ku-70 (K331) antibody (STJ90158)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Ku-70 (Acetyl Lys331) Polyclonal Antibody.
Check alternative names for the antibodyExpand
XRCC6 antibody, G22P1 antibody,|5”-deoxyribose-5-phosphate lyase Ku70 antibody|5”-dRP lyase Ku70 antibody|70 kDa subunit of Ku antigen antibody|ATP dependent DNA helicase 2 subunit 1 antibody|ATP dependent DNA helicase II 70 kDa subunit antibody|ATP-dependent DNA helicase 2 subunit 1 antibody|ATP-dependent DNA helicase II 70 kDa subunit antibody|CTC box binding factor 75 kDa subunit antibody|CTC box-binding factor 75 kDa subunit antibody|CTC75 antibody|CTCBF antibody|DNA repair protein XRCC6 antibody|G22P1 antibody|Ku 70 antibody|Ku autoantigen p70 subunit antibody|Ku autoantigen, 70kDa antibody|Ku p70 antibody|Ku70 antibody|Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody|Kup70 antibody|Lupus Ku autoantigen protein p70 antibody|ML8 antibody|Thyroid autoantigen 70kD (Ku antigen) antibody|Thyroid autoantigen antibody|Thyroid lupus autoantigen antibody|Thyroid lupus autoantigen p70 antibody|Thyroid-lupus autoantigen antibody|TLAA antibody|X ray repair complementing defective repair in Chinese hamster cells 6 antibody|X-ray repair complementing defective repair in Chinese hamster cells 6 antibody|X-ray repair cross-complementing protein 6 antibody|XRCC 6 antibody|Xrcc6 antibody|XRCC6_HUMAN antibody|Anti-Ku70 antibody [N3H10] (ab3114)
SCBT cat No: sc-71470|sc-135963|sc-12729|sc-71469|sc-5309|sc-1486|sc-17789|sc-166386|sc-55505|sc-9033|sc-365766|sc-1487|sc-56129|sc-56130|sc-56131|sc-71471|sc-65575|
Ku-70 (Acetyl Lys331) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Acetyl-Ku-70 (K331) Polyclonal Antibody detects endogenous levels of Ku-70 protein only when acetylated at K331.
Synthesized acetyl-peptide derived from human Ku-70 around the acetylation site of K331
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Ku-70 (Acetyl Lys331) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Ku-70 (Acetyl Lys331) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
X-ray repair cross-complementing protein 6 antibody, 5′-deoxyribose-5-phosphate lyase Ku70 antibody, 5′-dRP lyase Ku70 antibody, 70 kDa subunit of Ku antigen antibody, ATP-dependent DNA helicase 2 subunit 1 antibody, ATP-dependent DNA helicase II 70 kDa subunit antibody, CTC box-binding factor 75 kDa subunit antibody, CTC75 antibody, CTCBF antibody, DNA repair protein XRCC6 antibody, Lupus Ku autoantigen protein p70 antibody, Ku70 antibody, Thyroid-lupus autoantigen antibody, TLAA antibody, X-ray repair complementing defective repair in Chinese hamster cells 6 antibody
|Protein names|| |
X-ray repair cross-complementing protein 6 , 5′-deoxyribose-5-phosphate lyase Ku70 , 5′-dRP lyase Ku70 , 70 kDa subunit of Ku antigen , ATP-dependent DNA helicase 2 subunit 1 , ATP-dependent DNA helicase II 70 kDa subunit , CTC box-binding factor 75 kDa subunit , CTC75 , CTCBF , DNA repair protein XRCC6 , Lupus Ku autoantigen protein p70 , Ku70 , Thyroid-lupus autoantigen , TLAA , X-ray repair complementing defective repair in Chinese hamster cells 6
|Protein function|| |
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5′-deoxyribose-5-phosphate lyase (5′-dRP lyase), by catalyzing the beta-elimination of the 5′ deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5′-dRP lyase activity allows to ‘clean’ the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.
|Protein tissue specificity|| |
Expression does not increase during promyelocyte differentiation.
|Protein sequence and domain|| |
Belongs to the ku70 family. / Contains 1 Ku domain. / Contains 1 SAP domain.
|Protein post-translational modifications|| |
Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.
|Protein cellular localization|| |
Nucleus / Chromosome
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St John’s Laboratory Ltd.
|Product type|| |
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