Rabbit Polyclonal Acetyl-Ku-70 (K542) antibody (STJ90148)

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Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Acetyl-Ku-70 (K542) antibody (STJ90148)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC-P 1:100-300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Ku-70 (Acetyl Lys542) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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XRCC6 antibody, G22P1 antibody,|5”-deoxyribose-5-phosphate lyase Ku70 antibody|5”-dRP lyase Ku70 antibody|70 kDa subunit of Ku antigen antibody|ATP dependent DNA helicase 2 subunit 1 antibody|ATP dependent DNA helicase II 70 kDa subunit antibody|ATP-dependent DNA helicase 2 subunit 1 antibody|ATP-dependent DNA helicase II 70 kDa subunit antibody|CTC box binding factor 75 kDa subunit antibody|CTC box-binding factor 75 kDa subunit antibody|CTC75 antibody|CTCBF antibody|DNA repair protein XRCC6 antibody|G22P1 antibody|Ku 70 antibody|Ku autoantigen p70 subunit antibody|Ku autoantigen, 70kDa antibody|Ku p70 antibody|Ku70 antibody|Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody|Kup70 antibody|Lupus Ku autoantigen protein p70 antibody|ML8 antibody|Thyroid autoantigen 70kD (Ku antigen) antibody|Thyroid autoantigen antibody|Thyroid lupus autoantigen antibody|Thyroid lupus autoantigen p70 antibody|Thyroid-lupus autoantigen antibody|TLAA antibody|X ray repair complementing defective repair in Chinese hamster cells 6 antibody|X-ray repair complementing defective repair in Chinese hamster cells 6 antibody|X-ray repair cross-complementing protein 6 antibody|XRCC 6 antibody|Xrcc6 antibody|XRCC6_HUMAN antibody|Anti-Ku70 antibody [N3H10] (ab3114)
SCBT cat No: sc-71470|sc-135963|sc-12729|sc-71469|sc-5309|sc-1486|sc-17789|sc-166386|sc-55505|sc-9033|sc-365766|sc-1487|sc-56129|sc-56130|sc-56131|sc-71471|sc-65575|

 

Name

Ku-70 (Acetyl Lys542) Polyclonal Antibody

Catalogue No.

STJ90148

Reactivity

Human

Specificity

Acetyl-Ku-70 (K542) Polyclonal Antibody detects endogenous levels of Ku-70 protein only when acetylated at K542.

Immunogen

Synthesized acetyl-peptide derived from the human Ku-70 around the acetylation site of K542

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC-P 1:100-300; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

70 kDa

Formulation

Ku-70 (Acetyl Lys542) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Ku-70 (Acetyl Lys542) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

X-ray repair cross-complementing protein 6 antibody, 5′-deoxyribose-5-phosphate lyase Ku70 antibody, 5′-dRP lyase Ku70 antibody, 70 kDa subunit of Ku antigen antibody, ATP-dependent DNA helicase 2 subunit 1 antibody, ATP-dependent DNA helicase II 70 kDa subunit antibody, CTC box-binding factor 75 kDa subunit antibody, CTC75 antibody, CTCBF antibody, DNA repair protein XRCC6 antibody, Lupus Ku autoantigen protein p70 antibody, Ku70 antibody, Thyroid-lupus autoantigen antibody, TLAA antibody, X-ray repair complementing defective repair in Chinese hamster cells 6 antibody

Database links

Human UniProt/Swiss-Prot:P12956;Mouse UniPort/Swiss-Prot: P23475;Rat UniProt/Swiss-Port: Q6AZ64;Human Entrez Gene: 2547;Mouse Entrez Gene: 14375;Rat Entrez Gene: Rn.161996

Protein names

X-ray repair cross-complementing protein 6 , 5′-deoxyribose-5-phosphate lyase Ku70 , 5′-dRP lyase Ku70 , 70 kDa subunit of Ku antigen , ATP-dependent DNA helicase 2 subunit 1 , ATP-dependent DNA helicase II 70 kDa subunit , CTC box-binding factor 75 kDa subunit , CTC75 , CTCBF , DNA repair protein XRCC6 , Lupus Ku autoantigen protein p70 , Ku70 , Thyroid-lupus autoantigen , TLAA , X-ray repair complementing defective repair in Chinese hamster cells 6

Protein function

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5′-deoxyribose-5-phosphate lyase (5′-dRP lyase), by catalyzing the beta-elimination of the 5′ deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5′-dRP lyase activity allows to ‘clean’ the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

Protein tissue specificity

Expression does not increase during promyelocyte differentiation.

Protein sequence and domain

Belongs to the ku70 family. / Contains 1 Ku domain. / Contains 1 SAP domain.

Protein post-translational modifications

Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.

Protein cellular localization

Nucleus / Chromosome

Research area

All research areas>Tumor Suppressor/Apoptosis>Ku-70
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Ku-70 (Acetyl Lys542) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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