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Rabbit Polyclonal Acetyl-Ku-70 (K542) antibody (STJ90148)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC-P 1:100-300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Ku-70 (Acetyl Lys542) Polyclonal Antibody.
Check alternative names for the antibodyExpand
XRCC6 antibody, G22P1 antibody,|5”-deoxyribose-5-phosphate lyase Ku70 antibody|5”-dRP lyase Ku70 antibody|70 kDa subunit of Ku antigen antibody|ATP dependent DNA helicase 2 subunit 1 antibody|ATP dependent DNA helicase II 70 kDa subunit antibody|ATP-dependent DNA helicase 2 subunit 1 antibody|ATP-dependent DNA helicase II 70 kDa subunit antibody|CTC box binding factor 75 kDa subunit antibody|CTC box-binding factor 75 kDa subunit antibody|CTC75 antibody|CTCBF antibody|DNA repair protein XRCC6 antibody|G22P1 antibody|Ku 70 antibody|Ku autoantigen p70 subunit antibody|Ku autoantigen, 70kDa antibody|Ku p70 antibody|Ku70 antibody|Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody|Kup70 antibody|Lupus Ku autoantigen protein p70 antibody|ML8 antibody|Thyroid autoantigen 70kD (Ku antigen) antibody|Thyroid autoantigen antibody|Thyroid lupus autoantigen antibody|Thyroid lupus autoantigen p70 antibody|Thyroid-lupus autoantigen antibody|TLAA antibody|X ray repair complementing defective repair in Chinese hamster cells 6 antibody|X-ray repair complementing defective repair in Chinese hamster cells 6 antibody|X-ray repair cross-complementing protein 6 antibody|XRCC 6 antibody|Xrcc6 antibody|XRCC6_HUMAN antibody|Anti-Ku70 antibody [N3H10] (ab3114)
SCBT cat No: sc-71470|sc-135963|sc-12729|sc-71469|sc-5309|sc-1486|sc-17789|sc-166386|sc-55505|sc-9033|sc-365766|sc-1487|sc-56129|sc-56130|sc-56131|sc-71471|sc-65575|
Ku-70 (Acetyl Lys542) Polyclonal Antibody
|Catalogue No.|| |
Acetyl-Ku-70 (K542) Polyclonal Antibody detects endogenous levels of Ku-70 protein only when acetylated at K542.
Synthesized acetyl-peptide derived from the human Ku-70 around the acetylation site of K542
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC-P 1:100-300; ELISA 1:20000;
|Molecular weight|| |
Ku-70 (Acetyl Lys542) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Ku-70 (Acetyl Lys542) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
X-ray repair cross-complementing protein 6 antibody, 5'-deoxyribose-5-phosphate lyase Ku70 antibody, 5'-dRP lyase Ku70 antibody, 70 kDa subunit of Ku antigen antibody, ATP-dependent DNA helicase 2 subunit 1 antibody, ATP-dependent DNA helicase II 70 kDa subunit antibody, CTC box-binding factor 75 kDa subunit antibody, CTC75 antibody, CTCBF antibody, DNA repair protein XRCC6 antibody, Lupus Ku autoantigen protein p70 antibody, Ku70 antibody, Thyroid-lupus autoantigen antibody, TLAA antibody, X-ray repair complementing defective repair in Chinese hamster cells 6 antibody
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P12956">P12956</a>;Mouse UniPort/Swiss-Prot: <a href="http://www.uniprot.org/uniprot/P23475">P23475</a>;Rat UniProt/Swiss-Port: <a href="http://www.uniprot.org/uniprot/Q6AZ64">Q6AZ64</a>;Human Entrez Gene: <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2547">2547</a>;Mouse Entrez Gene: <a href="http://www.ncbi.nlm.nih.gov/gene/14375">14375</a>;Rat Entrez Gene: <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=161996">Rn.161996</a>
|Protein names|| |
X-ray repair cross-complementing protein 6 , 5'-deoxyribose-5-phosphate lyase Ku70 , 5'-dRP lyase Ku70 , 70 kDa subunit of Ku antigen , ATP-dependent DNA helicase 2 subunit 1 , ATP-dependent DNA helicase II 70 kDa subunit , CTC box-binding factor 75 kDa subunit , CTC75 , CTCBF , DNA repair protein XRCC6 , Lupus Ku autoantigen protein p70 , Ku70 , Thyroid-lupus autoantigen , TLAA , X-ray repair complementing defective repair in Chinese hamster cells 6
|Protein function|| |
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.
|Protein tissue specificity|| |
Expression does not increase during promyelocyte differentiation.
|Protein sequence and domain|| |
Belongs to the ku70 family. / Contains 1 Ku domain. / Contains 1 SAP domain.
|Protein post-translational modifications|| |
Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.
|Protein cellular localization|| |
Nucleus / Chromosome
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/Ku-70/">Ku-70</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"> (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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