Rabbit Polyclonal Acetyl-p73 (K327) antibody (STJ90153)

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Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Acetyl-p73 (K327) antibody (STJ90153)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for p73 (Acetyl Lys327) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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TP73 antibody, P73 antibody,|p53 like transcription factor antibody|p53-like transcription factor antibody|p73 antibody|P73_HUMAN antibody|TP73 antibody|Tumor protein p73 antibody|Anti-p73 antibody [EP436Y] (ab40658)
SCBT cat No: sc-56086|sc-70966|sc-23429|sc-517013|sc-14190|sc-28281|sc-14187|sc-517236|sc-10473|sc-10471|sc-15373|sc-14194|

 

Name

p73 (Acetyl Lys327) Polyclonal Antibody

Catalogue No.

STJ90153

Reactivity

Human, Mouse, Rat

Specificity

Acetyl-p73 (K327) Polyclonal Antibody detects endogenous levels of p73 protein only when acetylated at K327.

Immunogen

Synthesized acetyl-peptide derived from the human p73 around the acetylation site of K327

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

70 kDa

Formulation

p73 (Acetyl Lys327) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

p73 (Acetyl Lys327) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tumor protein p73 antibody, p53-like transcription factor antibody, p53-related protein antibody

Database links

Human UniProt/Swiss-Prot:O15350;Mouse UniPort/Swiss-Prot: Q9JJP2;Rat UniProt/Swiss-Port: D4AA88;Human Entrez Gene: 7161;Mouse Entrez Gene: 22062;Rat Entrez Gene: Rn.103860

Protein names

Tumor protein p73 , p53-like transcription factor , p53-related protein

Protein function

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. / Zn2+

Protein tissue specificity

Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.

Protein sequence and domain

Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL1 tyrosine kinase SH3 domain. / The WW-binding motif mediates interaction with WWOX. / Belongs to the p53 family. / Contains 1 SAM (sterile alpha motif) domain.

Protein post-translational modifications

Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function. / Higher levels of phosphorylation seen in the brain from patients with Huntington disease. / Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.

Protein cellular localization

Nucleus / Cytoplasm

Research area

All research areas>Tumor Suppressor/Apoptosis>p73
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize p73 (Acetyl Lys327) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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