Rabbit polyclonal ACHE antibody (A2806)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ACHE antibody (A2806)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

YT antibody, ACEE antibody, ARACHE antibody, N-ACHE antibody
ACEE antibody|ARACHE antibody|N ACHE antibody|N-ACHE antibody|YT antibody|YT blood group antibody|Anti-Acetylcholinesterase antibody [HR2] (ab2803)

SCBT cat No: sc-6432|

Name

Rabbit polyclonal ACHE antibody

Catalogue No.

A2806

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ACHE

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 68kDa/Observed: Refer to figures

Formulation

ACHE antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ACHE antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

YT antibody, ACEE antibody, ARACHE antibody, N-ACHE antibody

Database links

Human UniProt/Swiss-Prot:P22303

Protein names

YT, ACEE, ARACHE, N-ACHE

Protein function

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.

Protein tissue specificity

Isoform H is highly expressed in erythrocytes.

Protein sequence and domain

Belongs to the type-B carboxylesterase/lipase family.

Protein cellular localization

Cell junction, synapse . Secreted . Cell membrane ; Peripheral membrane protein .; Isoform T: Nucleus. Note: Only observed in apoptotic nuclei.; Isoform H: Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side .

Background

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.

Research area

All research areas>Neurobiology>AChE
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize ACHE antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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