Rabbit polyclonal ACTB antibody (AC006)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ACTB antibody (AC006)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ACTB antibody.

Alternative names:

Check alternative names for the antibody

Expand

Actin-beta antibody, BRWS1 antibody, PS1TP5BP1 antibody
A26C1A antibody|A26C1B antibody|ACTB antibody|ACTB_HUMAN antibody|Actin cytoplasmic 1 antibody|Actin, cytoplasmic 1, N-terminally processed antibody|Actx antibody|b actin antibody|Beta cytoskeletal actin antibody|Beta-actin antibody|BRWS1 antibody|E430023M04Rik antibody|MGC128179 antibody|PS1TP5 binding protein 1 antibody|PS1TP5BP1 antibody|Anti-beta Actin antibody [mAbcam 8224] – Loading Control (ab8224)

SCBT cat No: sc-56499|sc-166524|sc-7454|sc-17829|sc-15335|sc-7453|sc-135819|sc-393495|

Name

Rabbit polyclonal ACTB antibody

Catalogue No.

AC006

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ACTB

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to figures

Formulation

ACTB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ACTB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Actin-beta antibody, BRWS1 antibody, PS1TP5BP1 antibody

Database links

Human UniProt/Swiss-Prot:P60709

Protein names

BRWS1, PS1TP5BP1

Protein function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Protein sequence and domain

Belongs to the actin family.

Protein post-translational modifications

ISGylated.; Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).; Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.; (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding . The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners .

Protein cellular localization

Cytoplasm, cytoskeleton . Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Background

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins.

Research area

All research areas>Structural Proteins>Actin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize ACTB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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