Rabbit polyclonal ACTL6A antibody (A5387)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,CHIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ACTL6A antibody (A5387)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,CHIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:50 – 1:200 ChIP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ACTL6A antibody.

Alternative names:

Check alternative names for the antibody

Expand

Arp4 antibody, ACTL6 antibody, BAF53A antibody, INO80K antibody, ARPN-BETA antibody
53 kDa BRG1 associated factor A antibody|ACTL 6 antibody|ACTL 6A antibody|ACTL6 antibody|ACTL6A antibody|Arp4 antibody|ARPN BETA antibody|ArpNbeta antibody|BAF 53 antibody|BAF 53A antibody|BAF complex 53 kDa subunit antibody|BAF53 antibody|BRG1 associated factor 53A antibody|BRG1 associated factor antibody|BRG1/brm associated factor 53A antibody|hArpN beta antibody|INO80 complex subunit K antibody|INO80K antibody|MGC5382 antibody|Anti-BAF53A antibody – ChIP Grade (ab3882)

SCBT cat No: sc-137063|sc-271011|sc-271226|sc-271177|sc-137062|sc-137081|sc-47808|

Name

Rabbit polyclonal ACTL6A antibody

Catalogue No.

A5387

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ACTL6A

Host

Rabbit

Applications

WB, IHC, IF, IP, CHIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:50 – 1:200
ChIP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 47kDa/Observed: Refer to Figures

Formulation

ACTL6A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ACTL6A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Arp4 antibody, ACTL6 antibody, BAF53A antibody, INO80K antibody, ARPN-BETA antibody

Database links

Human UniProt/Swiss-Prot:O96019

Protein names

Arp4, ACTL6, BAF53A, INO80K, ARPN-BETA

Protein function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome – DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Protein sequence and domain

Belongs to the actin family.

Protein cellular localization

Nucleus .

Background

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.

Research area

All research areas>Transcription Regulators>BAF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize ACTL6A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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