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Rabbit polyclonal ACTL6B antibody (A7108)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal ACTL6B antibody.
Check alternative names for the antibodyExpand
ACTL6 antibody, BAF53B antibody
53 kDa BRG1 associated factor B antibody|Actl 6 antibody|ACTL 6B antibody|Actl6 antibody|ACTL6 B antibody|Actl6b antibody|Arp Na antibody|ArpN a antibody|ArpN alpha antibody|ArpNa antibody|ArpNalpha antibody|Baf 53b antibody|BAF53B antibody|BRG1-associated factor 53B antibody|Anti-BAF53b antibody [EPR10100(B)] (ab140642)
SCBT cat No:
Rabbit polyclonal ACTL6B antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human ACTL6B
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 47kDa/Observed: Refer to figures
ACTL6B antibody was tube-contained.
ACTL6B antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
ACTL6 antibody, BAF53B antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).
|Protein sequence and domain|| |
Belongs to the actin family.
|Protein cellular localization|| |
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.
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|Product type|| |
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