No products in the cart.
Home/Products/Product type/Primary antibody
Rabbit polyclonal ACTL6B antibody (A7108)
$69.00–$259.00
Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.
Rabbit polyclonal ACTL6B antibody (A7108)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
Recommended dilution:
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
Image descriptions:
Click or hover above images to see image description for Rabbit polyclonal ACTL6B antibody.
Alternative names:
Check alternative names for the antibody
ExpandACTL6 antibody, BAF53B antibody
53 kDa BRG1 associated factor B antibody|Actl 6 antibody|ACTL 6B antibody|Actl6 antibody|ACTL6 B antibody|Actl6b antibody|Arp Na antibody|ArpN a antibody|ArpN alpha antibody|ArpNa antibody|ArpNalpha antibody|Baf 53b antibody|BAF53B antibody|BRG1-associated factor 53B antibody|Anti-BAF53b antibody [EPR10100(B)] (ab140642)
SCBT cat No:
| Name | Rabbit polyclonal ACTL6B antibody |
|---|---|
| Catalogue No. | A7108 |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Recombinant protein of human ACTL6B |
| Host | Rabbit |
| Applications | WB, IHC, IF |
| Recommended dilution | WB 1:500 – 1:2000 |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Molecular weight | Predicted: 47kDa/Observed: Refer to figures |
| Formulation | ACTL6B antibody was tube-contained. |
| Purification | ACTL6B antibody was purified using affinity purification. |
| Storage | Store at -20 Celsius degree. Avoid freeze / thaw cycles. |
| Alternative antibody names | ACTL6 antibody, BAF53B antibody |
| Database links | Human UniProt/Swiss-Prot:O94805 |
| Protein names | ACTL6, BAF53B |
| Protein function | Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity). |
| Protein sequence and domain | Belongs to the actin family. |
| Protein cellular localization | Nucleus. |
| Background | The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. |
| Note | AntibodyPlus can customize ACTL6B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation. |
| Product type | Primary antibody |
| Supplier | ABclonal Inc. |
There are no reviews for this product yet.
By submitting a review, get following benefits:
1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!
There is no extra validation for this product yet.
Check other extra validated antibodies below:
Reviews
There are no reviews yet.