Rabbit polyclonal ACTN1 antibody (A1160)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ACTN1 antibody (A1160)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ACTN1 antibody.

Alternative names:

Check alternative names for the antibody

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ACTN1 antibody,FLJ40884 antibody,FLJ54432 antibody
actinin 1 smooth muscle antibody|Actinin alpha 1 antibody|actinin, alpha 1 antibody|ACTN 1 antibody|Actn1 antibody|ACTN1_HUMAN antibody|Alpha Actinin 1 antibody|Alpha actinin cytoskeletal isoform antibody|Alpha-actinin cytoskeletal isoform antibody|Alpha-actinin-1 antibody|BDPLT15 antibody|F actin cross linking protein antibody|F-actin cross-linking protein antibody|FLJ40884 antibody|FLJ54432 antibody|Non muscle alpha actinin 1 antibody|Non-muscle alpha-actinin-1 antibody|Anti-alpha Actinin antibody [0.T.02] (ab18061)

SCBT cat No: sc-7454|sc-17829|sc-15335|sc-7453|

Name

Rabbit polyclonal ACTN1 antibody

Catalogue No.

A1160

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ACTN1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 103kDa/Observed: Refer to Figures

Formulation

ACTN1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ACTN1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ACTN1 antibody,FLJ40884 antibody,FLJ54432 antibody

Database links

Human UniProt/Swiss-Prot:P12814

Protein names

ACTN1,FLJ40884,FLJ54432

Protein function

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

Protein sequence and domain

Belongs to the alpha-actinin family.; Contains 1 actin-binding domain.; Contains 2 CH (calponin-homology) domains.; Contains 2 EF-hand domains.; Contains 4 spectrin repeats.

Protein cellular localization

Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Cell membrane . Cell junction . Cell projection, ruffle . Note: Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures (By similarity).

Background

alpha-Actinin belongs to the spectrin family of cytoskeletal proteins. It was first recognized as an actin cross-linking protein, forming an antiparallel homodimer with an actin binding head at the amino terminus of each monomer. More recently, alpha-actinin has been shown to interact with a large number of proteins involved in signaling to the cytoskeleton including those involved in cellular adhesion, migration, and immune cell targeting (1). The interaction of alpha-actinin with intercellular adhesion molecule-5 (ICAM-5) helps to promote neurite outgrowth (2). In osteoblasts, interaction of alpha-actinin with integrins stabilizes focal adhesions and may protect cells from apoptosis (3). Isoforms 1 and 4 of alpha-actinin, which are non-muscle isoforms, are present in stress fibers, sites of adhesion and intercellular contacts, filopodia, and lamellipodia. The muscle isoforms 2 and 3 localize to the Z-discs of striated muscle and to dense bodies and plaques in smooth muscle (1).

Note

AntibodyPlus can customize ACTN1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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