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Rabbit polyclonal ACTR3 antibody (A1064)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal ACTR3 antibody.
Check alternative names for the antibodyExpand
ACTR3 antibody,ARP3 antibody
SCBT cat No:
Rabbit polyclonal ACTR3 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human ACTR3
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 47kDa/Observed: Refer to Figures
ACTR3 antibody was tube-contained.
ACTR3 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
ACTR3 antibody,ARP3 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.
|Protein sequence and domain|| |
Belongs to the actin family. ARP3 subfamily.
|Protein cellular localization|| |
Cytoplasm, cytoskeleton . Cell projection . Note: In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) .
Actin nucleation, the formation of new actin filaments from existing filaments, affects actin filament structure during cell motility, division, and intracellular trafficking. An important actin nucleation protein complex is the highly conserved ARP2/3 complex, consisting of ARP2, ARP3, and ARPC1-5. The ARP2/3 complex promotes branching of an existing actin filament and formation of a daughter filament following activation by nucleation-promoting factors, such as WASP/WAVE or cortactin (1). The formation of podosomes, small cellular projections that degrade the extracellular matrix, is enhanced by ARP2/3 complex action. ARP2/3 competes with caldesmon, an actin binding protein shown to negatively affect podosome formation (2). Along with N-WASP, the ARP2/3 complex regulates nuclear actin filament nucleation and controls actin polymerization during transcription (3).
AntibodyPlus can customize ACTR3 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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