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Rabbit Polyclonal ADAM10 antibody (STJ90014)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
ADAM10 antibody, KUZ antibody, MADM antibody,|A disintegrin and metalloprotease domain 10 antibody|A disintegrin and metalloproteinase domain 10 antibody|AD 10 antibody|AD10 antibody|AD18 antibody|ADA10_HUMAN antibody|ADAM 10 antibody|ADAM metallopeptidase domain 10 antibody|ADAM10 antibody|CD 156c antibody|CD156c antibody|CD156c antigen antibody|CDw156 antibody|disintegrin and metalloproteinase domain containing protein 10 antibody|Disintegrin and metalloproteinase domain-containing protein 10 antibody|HsT 18717 antibody|HsT18717 antibody|Kuz antibody|Kuzbanian antibody|Kuzbanian protein homolog antibody|Kuzbanian, Drosophila, homolog of antibody|MADM antibody|Mammalian disintegrin metalloprotease antibody|Mammalian disintegrin-metalloprotease antibody|RAK antibody|Anti-ADAM10 antibody (ab1997)
SCBT cat No: sc-16524|sc-48400|sc-28358|sc-25578|sc-16523|sc-31855|
ADAM10 Polyclonal Antibody
|Catalogue No.|| |
ADAM10 Polyclonal Antibody detects endogenous levels of ADAM10 protein.
Synthesized peptide derived from ADAM10 at AA range 170-250
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
ADAM10 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ADAM10 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Disintegrin and metalloproteinase domain-containing protein 10 antibody, ADAM 10 antibody, CDw156 antibody, Kuzbanian protein homolog antibody, Mammalian disintegrin-metalloprotease antibody, CD antigen CD156c antibody
|Protein names|| |
Disintegrin and metalloproteinase domain-containing protein 10 , ADAM 10 , CDw156 , Kuzbanian protein homolog , Mammalian disintegrin-metalloprotease , CD antigen CD156c
|Protein function|| |
Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-, -Val-77′ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling. / Endopeptidase of broad specificity. / Zn2+
|Protein tissue specificity|| |
Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
|Involvement in disease|| |
Reticulate acropigmentation of Kitamura (RAK) [MIM:615537]: A rare cutaneous pigmentation disorder characterized by reticulate, slightly depressed, sharply demarcated brown macules without hypopigmentation, affecting the dorsa of the hands and feet and appearing in the first or second decade of life. The macules gradually darken and extend to the proximal regions of the extremities. The manifestations tend to progress until middle age, after which progression of the eruptions stops. The pigmentary augmentation is found on the flexor aspects of the wrists, neck, patella and olecranon. Other features include breaks in the epidermal ridges on the palms and fingers, palmoplantar pits, occasionally plantar keratoderma, and partial alopecia. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Alzheimer disease 18 (AD18) [MIM:615590]: A late-onset form of Alzheimer disease, a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / The Cys-rich region C-terminal to the disintegrin domain functions as a substrate-recognition module, it recognizes the EFNA5-EPHA3 Complex but not the individual proteins. / Contains 1 disintegrin domain. / Contains 1 peptidase M12B domain.
|Protein post-translational modifications|| |
The precursor is cleaved by a furin endopeptidase.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein / Endomembrane system; Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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