Rabbit polyclonal ADAM12 antibody (A7940)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ADAM12 antibody (A7940)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ADAM12 antibody.

Alternative names:

Check alternative names for the antibody

Expand

MCMP antibody, MLTN antibody, CAR10 antibody, MLTNA antibody, MCMPMltna antibody, ADAM12-OT1 antibody
A disintegrin and metalloproteinase domain 12 antibody|ADA12_HUMAN antibody|ADAM 12 antibody|ADAM metallopeptidase domain 12 antibody|ADAM12 antibody|Disintegrin and metalloproteinase domain-containing protein 12 antibody|MCMP antibody|MCMPMltna antibody|Meltrin alpha antibody|Meltrin-alpha antibody|MLTN antibody|MLTNA antibody|OTTHUMP00000046766 antibody|Anti-ADAM12 antibody – Aminoterminal end (ab39155)

SCBT cat No: sc-293225|sc-16527|sc-25579|

Name

Rabbit polyclonal ADAM12 antibody

Catalogue No.

A7940

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ADAM12

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:100 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 100kDa/Observed: Refer to figures

Formulation

ADAM12 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ADAM12 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MCMP antibody, MLTN antibody, CAR10 antibody, MLTNA antibody, MCMPMltna antibody, ADAM12-OT1 antibody

Database links

Human UniProt/Swiss-Prot:O43184

Protein names

MCMP, MLTN, CAR10, MLTNA, MCMPMltna, ADAM12-OT1

Protein function

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).

Protein tissue specificity

Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.

Protein sequence and domain

The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.; The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.Contains 1 disintegrin domain.; Contains 1 EGF-like domain.; Contains 1 peptidase M12B domain.

Protein post-translational modifications

The precursor is cleaved by a furin endopeptidase.

Protein cellular localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted .; Isoform 4: Secreted .

Background

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form.

Research area

All research areas>Synthesis and Degradation>ADAM
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize ADAM12 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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