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Rabbit Polyclonal ADAM28 antibody (A9512)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal ADAM28 antibody.
Check alternative names for the antibodyExpand
A disintegrin and metalloproteinase domain 28 antibody|ADAM 28 antibody|ADAM metallopeptidase domain 28 antibody|ADAM23 antibody|Disintegrin and metalloproteinase domain containing protein 28 antibody|eMDC II antibody|eMDCII antibody|epididymal Metalloproteinase like disintegrin like and cysteine rich protein II antibody|MDC L antibody|MDCL antibody|Metalloproteinase like disintegrin like and cysteine rich protein L antibody|Anti-ADAM28 antibody – Aminoterminal end (ab28292)
SCBT cat No: sc-393877|sc-367054|
Rabbit Polyclonal ADAM28 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human ADAM28
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
ADAM28 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/Q9UKQ2">Q9UKQ2</a>
|Protein function|| |
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
|Protein tissue specificity|| |
Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.
|Protein sequence and domain|| |
Contains 1 disintegrin domain.; Contains 1 EGF-like domain.; Contains 1 peptidase M12B domain. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
|Protein post-translational modifications|| |
Pro-domain removal and maturation may be, at least in part, autocatalytic.
|Protein cellular localization|| |
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
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|Product type|| |
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