Rabbit polyclonal ADAM9 antibody (A5388)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ADAM9 antibody (A5388)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ADAM9 antibody.

Alternative names:

Check alternative names for the antibody

Expand

MCMP antibody, MDC9 antibody, CORD9 antibody, Mltng antibody
A disintegrin and metalloproteinase domain 9 antibody|Cone rod dystrophy 9 antibody|CORD9 antibody|Disintegrin and metalloproteinase domain 9 antibody|Disintegrin and metalloproteinase domain containing protein 9 antibody|KIAA0021 antibody|MCMP antibody|MDC 9 antibody|MDC9 antibody|Meltrin gamma antibody|Metalloprotease disintegrin cysteine rich protein 9 antibody|Mltng antibody|Myeloma cell metalloproteinase antibody|Anti-ADAM9 antibody (ab186833)

SCBT cat No: sc-135822|sc-23290|sc-377233|sc-50332|

Name

Rabbit polyclonal ADAM9 antibody

Catalogue No.

A5388

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ADAM9

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 91kDa/Observed: Refer to Figures

Formulation

ADAM9 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ADAM9 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MCMP antibody, MDC9 antibody, CORD9 antibody, Mltng antibody

Database links

Human UniProt/Swiss-Prot:Q13443

Protein names

MCMP, MDC9, CORD9, Mltng

Protein function

Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.; Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP).

Protein tissue specificity

Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.

Protein sequence and domain

Contains 1 disintegrin domain.; Contains 1 EGF-like domain.; Contains 1 peptidase M12B domain.

Protein post-translational modifications

Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.; Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Secreted .

Background

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene.

Research area

All research areas>Synthesis and Degradation>ADAM
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize ADAM9 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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