Rabbit polyclonal ADCY1 antibody (A9760)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ADCY1 antibody (A9760)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:1000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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AC1 antibody, DFNB44 antibody
Adenylate cyclase 1, fetal brain, type I antibody|3′,5′-cyclic AMP synthetase antibody|AC1 antibody|Adcy1 antibody|ADCY1_HUMAN antibody|adenyl cyclase antibody|Adenylate cyclase 1 antibody|adenylate cyclase 1 (brain) antibody|Adenylate cyclase type 1 antibody|Adenylate cyclase type I antibody|Adenylyl cyclase 1 antibody|ATP pyrophosphate lyase antibody|ATP pyrophosphate-lyase 1 antibody|Brain adenylate cyclase 1 antibody|Ca(2+)/calmodulin-activated adenylyl cyclase antibody|deafness, autosomal recessive 44 antibody|DFNB44 antibody|Anti-Adenylate cyclase 1 antibody (ab69597)

SCBT cat No: sc-365350|sc-25743|sc-586|

Name

Rabbit polyclonal ADCY1 antibody

Catalogue No.

A9760

Reactivity

Human, Mouse

Immunogen

Recombinant Protein of human ADCY1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:200 – 1:1000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 123kDa/Observed: Refer to figures

Formulation

ADCY1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ADCY1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AC1 antibody, DFNB44 antibody

Database links

Human UniProt/Swiss-Prot:Q08828

Protein names

AC1, DFNB44

Protein function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).

Protein tissue specificity

Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) . Brain, retina and adrenal medulla.

Protein sequence and domain

The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.; Contains 2 guanylate cyclase domains.

Protein post-translational modifications

N-glycosylated.

Protein cellular localization

Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Membrane raft . Note: Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia.

Background

This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants.

Research area

All research areas>Signaling Intermediates>A cyclase
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize ADCY1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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