Rabbit polyclonal ADIPOQ antibody (A2543)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ADIPOQ antibody (A2543)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ADIPOQ antibody.

Alternative names:

Check alternative names for the antibody

Expand

ACDC antibody, ADPN antibody, APM1 antibody, APM-1 antibody, GBP28 antibody, ACRP30 antibody, ADIPQTL1 antibody
adipocyte-specific secretory protein antibody|Adiponectin antibody|Adiponectin precursor antibody|adiponectin, C1Q and collagen domain containing antibody|Adipoq antibody|Adipose most abundant gene transcript 1 antibody|Adipose most abundant gene transcript 1 protein antibody|Adipose specific collagen like factor antibody|ADIPQTL1 antibody|ADPN antibody|APM 1 antibody|apM-1 antibody|APM1 antibody|C1q and collagen domain-containing protein antibody|GBP28 antibody|Gelatin binding protein antibody|Gelatin binding protein 28 antibody|Gelatin-binding protein antibody|Anti-Adiponectin antibody [19F1] (ab22554)

SCBT cat No: sc-136131|sc-26497|sc-26496|sc-17044|

Name

Rabbit polyclonal ADIPOQ antibody

Catalogue No.

A2543

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ADIPOQ

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 26kDa/Observed: Refer to Figures

Formulation

ADIPOQ antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ADIPOQ antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ACDC antibody, ADPN antibody, APM1 antibody, APM-1 antibody, GBP28 antibody, ACRP30 antibody, ADIPQTL1 antibody

Database links

Human UniProt/Swiss-Prot:Q15848

Protein names

ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1

Protein function

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Protein tissue specificity

Synthesized exclusively by adipocytes and secreted into plasma.

Protein sequence and domain

The C1q domain is commonly called the globular domain.Contains 1 C1q domain.; Contains 1 collagen-like domain.

Protein post-translational modifications

Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal peptide in mass fingerprinting.; HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes (By similarity).; O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation.

Protein cellular localization

Secreted.

Background

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Research area

All research areas>Growth Factors and Hormones>Acrp30
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize ADIPOQ antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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