Rabbit polyclonal ADIPOR1 antibody (A1509)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ADIPOR1 antibody (A1509)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ADIPOR1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

Adiponectin receptor protein 1 antibody, Progestin and adipoQ receptor family member I antibody, CGI-45 antibody, PAQR1 antibody, ADIPOR1 antibody
ACDCR1 antibody|ADIPO R1 antibody|Adiponectin receptor protein 1 antibody|ADIPOR 1 antibody|Adipor1 antibody|ADR1_HUMAN antibody|CGI 45 antibody|CGI 45 protein antibody|CGI-45 antibody|CGI45 antibody|CGI45 protein antibody|FLJ25385 antibody|FLJ42464 antibody|PAQR1 antibody|Progestin and adipoQ receptor family member I antibody|TESBP1A antibody|Anti-Adiponectin Receptor 1 antibody [EPR6626] (ab126611)

SCBT cat No: sc-46748|sc-46749|

Name

Rabbit polyclonal ADIPOR1 antibody

Catalogue No.

A1509

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ADIPOR1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to Figures

Formulation

ADIPOR1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ADIPOR1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Adiponectin receptor protein 1 antibody, Progestin and adipoQ receptor family member I antibody, CGI-45 antibody, PAQR1 antibody, ADIPOR1 antibody

Database links

Human UniProt/Swiss-Prot:Q96A54

Protein names

Adiponectin receptor protein 1, Progestin and adipoQ receptor family member I, CGI-45, PAQR1, ADIPOR1

Protein function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism . Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Protein tissue specificity

Widely expressed . Highly expressed in heart and skeletal muscle . Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes . Weakly expressed in colon, thymus and small intestine .

Protein sequence and domain

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.Belongs to the ADIPOR family.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Note: Localized to the cell membrane and intracellular organelles.

Background

Adiponectin is a circulating hormone secreted by adipocytes that improves the metabolism of glucose and lipids, and is expressed at low levels in those with obesity and diabetes. Adiponectin receptors AdipoR1 and AdipoR2, also designated progestin and adipoQ receptor family members I and II, respectively, regulate fatty acid oxidation and the uptake of glucose by adiponectin. Each receptor activates a unique set of signaling molecules including AMPK, p38 MAPK and PPAR alpha. AdipoR1 has a high-affinity for globular adiponectin and low-affinity for full-length adiponectin, while AdipoR2 has an intermediate affinity for both forms. AdipoR1 and AdipoR2 are mainly expressed in liver and muscle. Adiponectin, AdipoR1 and AdipoR2 are all associated with body composition, Insulin sensitivity, and metabolic parameters. Physical training increases circulating adiponectin and mRNA expression of AdipoR1 and AdipoR2 in muscle, which may mediate the improvement of Insulin resistance and the metabolic syndrome in response to exercise.

Note

AntibodyPlus can customize ADIPOR1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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