Rabbit polyclonal ADRBK1 antibody (A1662)


Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ADRBK1 antibody (A1662)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


BARK1 antibody, BETA-ARK1 antibody, FLJ16718 antibody, GRK2 antibody
ADRBK1 antibody|Adrenergic beta receptor kinase 1 antibody|ARBK1_HUMAN antibody|BARK antibody|BARK1 antibody|Beta adrenergic receptor kinase 1 antibody|Beta ARK 1 antibody|Beta ARK1 antibody|Beta-adrenergic receptor kinase 1 antibody|Beta-ARK-1 antibody|FLJ16718 antibody|G protein coupled receptor kinase 2 antibody|G-protein coupled receptor kinase 2 antibody|GRK2 antibody|Anti-GRK2 antibody – C-terminal (ab137666)

SCBT cat No: sc-562|sc-18409|sc-13143|sc-166283|sc-166284|sc-271359|sc-8329|


Rabbit polyclonal ADRBK1 antibody

Catalogue No.



Human, Mouse, Rat


Recombinant protein of human ADRBK1





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200







Molecular weight

Predicted: 80kDa/Observed: Refer to Figures


ADRBK1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


ADRBK1 antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BARK1 antibody, BETA-ARK1 antibody, FLJ16718 antibody, GRK2 antibody

Database links

Human UniProt/Swiss-Prot:P25098

Protein names


Protein function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Protein tissue specificity

Expressed in peripheral blood leukocytes.

Protein sequence and domain

The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-alpha subunits and other G-betagamma effectors.Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.; Contains 1 AGC-kinase C-terminal domain.; Contains 1 PH domain.; Contains 1 protein kinase domain.; Contains 1 RGS domain.

Protein cellular localization

Cytoplasm . Cell membrane .


G-protein-coupled receptor kinase 2 (GRK2), also known as beta-adrenergic receptor kinase 1 (beta-ARK1), is a member of the GRK family, which phosphorylates the activated form of G-protein-coupled receptors (GPCRs) and initiates the desensitization process of GPCR (1). GRK2 kinase activity and cellular localization are tightly regulated by interactions with activated receptors, G-beta and G-gamma subunits, adaptor proteins, phospholipids, caveolin and calmodulin, as well as by phosphorylation (1). PKC phosphorylation enhances GRK2 activity by promoting its membrane localization and by abolishing the inhibitory association of calmodulin (2,3). PKA phosphorylates GRK2 at Ser685, which facilitates the association of GRK2 with a beta-adrenergic receptor (4). Erk inhibits GRK2 activity via phosphorylation at Ser670 (5). Src phosphorylates GRK2 at multiple tyrosine residues (Tyr13, 86 and 92), which activates GRK2 activity and promotes GRK2 degradation (6,7).

Research area

All research areas>Kinases and Phosphatases>GRK
(View all antibody categories related to Kinases and Phosphatases)


AntibodyPlus can customize ADRBK1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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