Rabbit polyclonal ADRBK1 antibody (A1662)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal ADRBK1 antibody (A1662)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ADRBK1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

BARK1 antibody, BETA-ARK1 antibody, FLJ16718 antibody, GRK2 antibody
ADRBK1 antibody|Adrenergic beta receptor kinase 1 antibody|ARBK1_HUMAN antibody|BARK antibody|BARK1 antibody|Beta adrenergic receptor kinase 1 antibody|Beta ARK 1 antibody|Beta ARK1 antibody|Beta-adrenergic receptor kinase 1 antibody|Beta-ARK-1 antibody|FLJ16718 antibody|G protein coupled receptor kinase 2 antibody|G-protein coupled receptor kinase 2 antibody|GRK2 antibody|Anti-GRK2 antibody – C-terminal (ab137666)

SCBT cat No: sc-562|sc-18409|sc-13143|sc-166283|sc-166284|sc-271359|sc-8329|

Name

Rabbit polyclonal ADRBK1 antibody

Catalogue No.

A1662

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ADRBK1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 80kDa/Observed: Refer to Figures

Formulation

ADRBK1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ADRBK1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BARK1 antibody, BETA-ARK1 antibody, FLJ16718 antibody, GRK2 antibody

Database links

Human UniProt/Swiss-Prot:P25098

Protein names

BARK1, BETA-ARK1, FLJ16718, GRK2

Protein function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Protein tissue specificity

Expressed in peripheral blood leukocytes.

Protein sequence and domain

The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-alpha subunits and other G-betagamma effectors.Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.; Contains 1 AGC-kinase C-terminal domain.; Contains 1 PH domain.; Contains 1 protein kinase domain.; Contains 1 RGS domain.

Protein cellular localization

Cytoplasm . Cell membrane .

Background

G-protein-coupled receptor kinase 2 (GRK2), also known as beta-adrenergic receptor kinase 1 (beta-ARK1), is a member of the GRK family, which phosphorylates the activated form of G-protein-coupled receptors (GPCRs) and initiates the desensitization process of GPCR (1). GRK2 kinase activity and cellular localization are tightly regulated by interactions with activated receptors, G-beta and G-gamma subunits, adaptor proteins, phospholipids, caveolin and calmodulin, as well as by phosphorylation (1). PKC phosphorylation enhances GRK2 activity by promoting its membrane localization and by abolishing the inhibitory association of calmodulin (2,3). PKA phosphorylates GRK2 at Ser685, which facilitates the association of GRK2 with a beta-adrenergic receptor (4). Erk inhibits GRK2 activity via phosphorylation at Ser670 (5). Src phosphorylates GRK2 at multiple tyrosine residues (Tyr13, 86 and 92), which activates GRK2 activity and promotes GRK2 degradation (6,7).

Research area

All research areas>Kinases and Phosphatases>GRK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize ADRBK1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!