Rabbit polyclonal ADSL antibody (A6278)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ADSL antibody (A6278)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ASL antibody, AMPS antibody, ASASE antibody
Adenylosuccinase antibody|Adenylosuccinate lyase antibody|ADSL antibody|AMPS antibody|ASase antibody|ASL antibody|OTTHUMP00000199172 antibody|OTTHUMP00000199173 antibody|PUR8_HUMAN antibody|Anti-Adenylosuccinate Lyase antibody [EPR10747(B)] (ab154182)

SCBT cat No: sc-365623|

Name

Rabbit polyclonal ADSL antibody

Catalogue No.

A6278

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ADSL

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 54kDa/Observed: Refer to Figures

Formulation

ADSL antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ADSL antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ASL antibody, AMPS antibody, ASASE antibody

Database links

Human UniProt/Swiss-Prot:P30566

Protein names

ASL, AMPS, ASASE

Protein function

Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.

Protein tissue specificity

Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.

Protein sequence and domain

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

Background

Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize ADSL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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