Rabbit polyclonal AES antibody (A7874)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal AES antibody (A7874)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

GRG antibody, ESP1 antibody, GRG5 antibody, TLE5 antibody, AES-1 antibody, AES-2 antibody, Grg-5 antibody
Aes 1 antibody|Protein ESP 1 antibody|Protein ESP1 antibody|Protein GRG antibody|TLE 5 antibody|TLE5 antibody|Anti-Amino-terminal enhancer of split antibody [EPR8385] (ab137060)

SCBT cat No:

Name

Rabbit polyclonal AES antibody

Catalogue No.

A7874

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human AES

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 22kDa/Observed: Refer to figures

Formulation

AES antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

AES antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GRG antibody, ESP1 antibody, GRG5 antibody, TLE5 antibody, AES-1 antibody, AES-2 antibody, Grg-5 antibody

Database links

Human UniProt/Swiss-Prot:Q08117

Protein names

GRG, ESP1, GRG5, TLE5, AES-1, AES-2, Grg-5

Protein function

Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.

Protein tissue specificity

Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

Protein sequence and domain

Lacks the C-terminal WD repeats.Belongs to the WD repeat Groucho/TLE family.

Protein post-translational modifications

Ubiquitinated by XIAP/BIRC4.

Protein cellular localization

Nucleus .

Background

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Transcription Regulators>TLE
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize AES antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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