Rabbit polyclonal AFAP1 antibody (A3478)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal AFAP1 antibody (A3478)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal AFAP1 antibody.

Alternative names:

Check alternative names for the antibody

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AFAP antibody, AFAP110 antibody, AFAP-110 antibody
110 kDa actin filament associated protein antibody|110 kDa actin filament-associated protein antibody|Actin filament associated protein 1 antibody|Actin filament associated protein 110 kDa antibody|Actin filament-associated protein 1 antibody|AFAP 1 antibody|AFAP 110 antibody|AFAP antibody|AFAP-110 antibody|Afap1 antibody|AFAP1_HUMAN antibody|AFAP110 antibody|FLJ56849 antibody|Anti-AFAP antibody [2G9] (ab170553)

SCBT cat No: sc-374655|

Name

Rabbit polyclonal AFAP1 antibody

Catalogue No.

A3478

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human AFAP1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:1000 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 81kDa/Observed: Refer to Figures

Formulation

AFAP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

AFAP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AFAP antibody, AFAP110 antibody, AFAP-110 antibody

Database links

Human UniProt/Swiss-Prot:Q8N556

Protein names

AFAP, AFAP110, AFAP-110

Protein function

Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

Protein tissue specificity

Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.

Protein sequence and domain

Contains 2 PH domains.

Protein post-translational modifications

Phosphorylated on tyrosine residues by SRC.

Protein cellular localization

Cytoplasm, cytoskeleton . Note: Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction.

Background

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize AFAP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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