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Rabbit polyclonal AGT antibody (A6279)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal AGT antibody.
Check alternative names for the antibodyExpand
ANHU antibody, SERPINA8 antibody
Aangiotensinogen (serpin peptidase inhibitor clade A member 8) antibody|AGT antibody|AI265500 antibody|Alpha 1 antiproteinase antitrypsin antibody|Ang antibody|Ang I antibody|Ang II antibody|Ang III antibody|AngII antibody|Angiotensin I antibody|Angiotensin II antibody|Angiotensin III antibody|Angiotensin-3 antibody|Angiotensinogen (PAT) antibody|Angiotensinogen antibody|ANGT_HUMAN antibody|ANHU antibody|ANRT antibody|AT-2 antibody|AT-II antibody|Des-Asp-angiotensin II antibody|FLJ92595 antibody|FLJ97926 antibody|MGC105326 antibody|PAT antibody|Pre angiotensinogen antibody|Serine (or cysteine) proteinase inhibitor antibody|Serpin A8 antibody|Serpin peptidase inhibitor clade A member 8 antibody|SERPINA8 antibody|Anti-Angiotensinogen antibody [EPR2931] (ab108334)
SCBT cat No: sc-374511|sc-20717|sc-7419|sc-80682|
Rabbit polyclonal AGT antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human AGT
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 53kDa/Observed: Refer to Figures
AGT antibody was tube-contained.
AGT antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
ANHU antibody, SERPINA8 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.; Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.; Angiotensin-3: stimulates aldosterone release.; Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
|Protein tissue specificity|| |
Expressed by the liver and secreted in plasma.
|Protein sequence and domain|| |
Belongs to the serpin family.
|Protein post-translational modifications|| |
Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.; In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).; The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
|Protein cellular localization|| |
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
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|Product type|| |
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