Rabbit polyclonal AIMP1 antibody (A5301)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal AIMP1 antibody (A5301)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal AIMP1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

p43 antibody, HLD3 antibody, EMAP2 antibody, SCYE1 antibody, EMAPII antibody
AIMP 1 antibody|Aimp1 antibody|AIMP1/p43 antibody|AIMP1_HUMAN antibody|Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 antibody|ARS interacting multifunctional protein 1 antibody|EMAP 2 antibody|EMAP-2 antibody|EMAP-II antibody|EMAP2 antibody|EMAPII antibody|Endothelial monocyte activating polypeptide 2 antibody|Endothelial monocyte activating polypeptide antibody|Endothelial monocyte-activating polypeptide 2 antibody|Endothelial monocyte-activating polypeptide II antibody|HLD3 antibody|Multisynthase complex auxiliary component p43 antibody|Multisynthetase complex auxiliary component p43 antibody|OTTHUMP00000219673 antibody|p43 antibody|Scye 1 antibody|Scye1 antibody|Scye1, formerly antibody|Small inducible cytokine subfamily E member 1 antibody|Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating) antibody|Small inducible cytokine subfamily E, member 1, formerly antibody|Anti-EMAP II antibody [546-2] (ab15693)

SCBT cat No: sc-136383|sc-32723|sc-393672|sc-393228|sc-393733|sc-271115|sc-66879|

Name

Rabbit polyclonal AIMP1 antibody

Catalogue No.

A5301

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human AIMP1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 34kDa/Observed: Refer to Figures

Formulation

AIMP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

AIMP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

p43 antibody, HLD3 antibody, EMAP2 antibody, SCYE1 antibody, EMAPII antibody

Database links

Human UniProt/Swiss-Prot:Q12904

Protein names

p43, HLD3, EMAP2, SCYE1, EMAPII

Protein function

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Protein sequence and domain

Contains 1 tRNA-binding domain.

Protein post-translational modifications

Cleaved by caspase-7 in response to apoptosis to produce EMAP-II.

Protein cellular localization

Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle . Secreted . Endoplasmic reticulum . Golgi apparatus . Note: Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death.

Background

The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20.

Research area

All research areas>Growth Factors and Hormones>EMAP II
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize AIMP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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