Rabbit polyclonal AIRE antibody (A1767)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal AIRE antibody (A1767)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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APS1 antibody, APSI antibody, PGA1 antibody, AIRE1 antibody, APECED antibody
AIRE antibody|AIRE_HUMAN antibody|AIRE1 antibody|APECED antibody|APECED protein antibody|APS1 antibody|APSI antibody|Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody|Autoimmune regulator antibody|Autoimmune regulator protein antibody|PGA1 antibody|Anti-AIRE antibody – ChIP Grade (ab13573)

SCBT cat No: sc-17986|sc-33188|sc-33189|sc-17985|

Name

Rabbit polyclonal AIRE antibody

Catalogue No.

A1767

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human AIRE

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 58kDa/Observed: Refer to Figures

Formulation

AIRE antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

AIRE antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

APS1 antibody, APSI antibody, PGA1 antibody, AIRE1 antibody, APECED antibody

Database links

Human UniProt/Swiss-Prot:O43918

Protein names

APS1, APSI, PGA1, AIRE1, APECED

Protein function

Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5′-. ATTGGTTA-3′ combined with a 5′-TTATTA-3′ box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at ‘Lys-4’, not phosphorylated at ‘Thr-3’ and not methylated at ‘Arg-2’. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.

Protein tissue specificity

Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.

Protein sequence and domain

The L-X-X-L-L repeats may be implicated in binding to nuclear receptors.; The HSR domain is required for localization on tubular structures (N-terminal part) and for homodimerization.; Interacts via the first PHD domain with the N-terminus of histone H3 that is not methylated at ‘Lys-4’. Disruption of the first PHD domain has been shown to lead to reduced transcriptional activity and to localization of the protein mainly in the cytoplasm in small granules. While the PHD zinc fingers are necessary for the transactivation capacity of the protein, other regions also modulate this function.Contains 1 HSR domain.; Contains 2 PHD-type zinc fingers.; Contains 1 SAND domain.

Protein post-translational modifications

Phosphorylated. Phosphorylation could trigger oligomerization.

Protein cellular localization

Nucleus. Cytoplasm. Note: Associated with tubular structures and in discrete nuclear dots resembling ND10 nuclear bodies. May shuttle between nucleus and cytoplasm.

Background

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]

Research area

All research areas>Transcription Regulators>AIRE-1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize AIRE antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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