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Rabbit polyclonal AK2 antibody (A6519)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal AK2 antibody.
Check alternative names for the antibodyExpand
ADK2 antibody, AK 2 antibody
Adenylate kinase 2 antibody|adenylate kinase 2, mitochondrial antibody|Adenylate kinase isoenzyme 2 antibody|ADK2 antibody|AK 2 antibody|ak2 antibody|ATP AMP transphosphorylase antibody|ATP-AMP transphosphorylase 2 antibody|EC 22.214.171.124 antibody|KAD2_HUMAN antibody|mitochondrial antibody|Anti-AK2 antibody (ab37594)
SCBT cat No: sc-374095|sc-28786|
Rabbit polyclonal AK2 antibody
|Catalogue No.|| |
Recombinant protein of human AK2
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 26kDa/Observed: Refer to figures
AK2 antibody was tube-contained.
AK2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
ADK2 antibody, AK 2 antibody
|Database links|| |
|Protein names|| |
ADK2, AK 2
|Protein function|| |
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
|Protein tissue specificity|| |
Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
|Protein sequence and domain|| |
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.Belongs to the adenylate kinase family. AK2 subfamily.
|Protein cellular localization|| |
Mitochondrion intermembrane space .
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
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|Product type|| |
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