Rabbit polyclonal AK2 antibody (A6519)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal AK2 antibody (A6519)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ADK2 antibody, AK 2 antibody
Adenylate kinase 2 antibody|adenylate kinase 2, mitochondrial antibody|Adenylate kinase isoenzyme 2 antibody|ADK2 antibody|AK 2 antibody|ak2 antibody|ATP AMP transphosphorylase antibody|ATP-AMP transphosphorylase 2 antibody|EC 2.7.4.3 antibody|KAD2_HUMAN antibody|mitochondrial antibody|Anti-AK2 antibody (ab37594)

SCBT cat No: sc-374095|sc-28786|

Name

Rabbit polyclonal AK2 antibody

Catalogue No.

A6519

Reactivity

Human

Immunogen

Recombinant protein of human AK2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 26kDa/Observed: Refer to figures

Formulation

AK2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

AK2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ADK2 antibody, AK 2 antibody

Database links

Human UniProt/Swiss-Prot:P54819

Protein names

ADK2, AK 2

Protein function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.

Protein tissue specificity

Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).

Protein sequence and domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.Belongs to the adenylate kinase family. AK2 subfamily.

Protein cellular localization

Mitochondrion intermembrane space .

Background

Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.

Research area

All research areas>Kinases and Phosphatases>Adenylate Kinase
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize AK2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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