Rabbit polyclonal AKR1C4 antibody (A7430)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal AKR1C4 antibody (A7430)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal AKR1C4 antibody.

Alternative names:

Check alternative names for the antibody

Expand

C11 antibody, CDR antibody, DD4 antibody, CHDR antibody, DD-4 antibody, HAKRA antibody, 3-alpha-HSD antibody
3 alpha HSD1 antibody|3-alpha-HSD1 antibody|3-alpha-hydroxysteroid dehydrogenase type I antibody|AK1C4_HUMAN antibody|AKR1C4 antibody|Aldo keto reductase family 1 member C4 antibody|Aldo-keto reductase family 1 member C4 antibody|CDR antibody|Chlordecone reductase antibody|DD-4 antibody|DD4 antibody|Dihydrodiol dehydrogenase 4 antibody|HAKRA antibody|Anti-HSD3a antibody (ab54606)

SCBT cat No: sc-100526|

Name

Rabbit polyclonal AKR1C4 antibody

Catalogue No.

A7430

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human AKR1C4

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to figures

Formulation

AKR1C4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

AKR1C4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

C11 antibody, CDR antibody, DD4 antibody, CHDR antibody, DD-4 antibody, HAKRA antibody, 3-alpha-HSD antibody

Database links

Human UniProt/Swiss-Prot:P17516

Protein names

C11, CDR, DD4, CHDR, DD-4, HAKRA, 3-alpha-HSD

Protein function

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Protein tissue specificity

Liver specific.

Protein sequence and domain

Belongs to the aldo/keto reductase family.

Protein post-translational modifications

The N-terminus is blocked.

Protein cellular localization

Cytoplasm.

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Research area

All research areas>Synthesis and Degradation>DD
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize AKR1C4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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