Rabbit polyclonal ALKBH1 antibody (A6240)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ALKBH1 antibody (A6240)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ALKBH1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ABH antibody, ABH1 antibody, alkB antibody, hABH antibody, ALKBH antibody
ABH antibody|ABH1 antibody|alkB antibody|alkB homolog 1 histone H2A dioxygenase antibody|AlkB, alkylation repair homolog 1 (E. coli) antibody|ALKB1_HUMAN antibody|ALKBH antibody|ALKBH1 antibody|Alkylated DNA repair protein alkB homolog 1 antibody|Alkylation repair homolog 1 antibody|Alkylation repair, alkB homolog antibody|Alpha-ketoglutarate-dependent dioxygenase ABH1 antibody|DNA lyase ABH1 antibody|DNA oxidative demethylase ALKBH1 antibody|hABH antibody|Anti-ALKBH1 antibody [EPR6176] (ab126596)

SCBT cat No: sc-374301|

Name

Rabbit polyclonal ALKBH1 antibody

Catalogue No.

A6240

Reactivity

Human

Immunogen

Recombinant protein of human ALKBH1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to Figures

Formulation

ALKBH1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ALKBH1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ABH antibody, ABH1 antibody, alkB antibody, hABH antibody, ALKBH antibody

Database links

Human UniProt/Swiss-Prot:Q13686

Protein names

ABH, ABH1, alkB, hABH, ALKBH

Protein function

Dioxygenase that acts as a DNA demethylase . Requires molecular oxygen, alpha-ketoglutarate and iron . Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity). Also able to repair alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation, but with low activity . Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites . DNA lyase activity does not require alpha-ketoglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5′ DNA product . DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity).

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

Belongs to the alkB family.; Contains 1 Fe2OG dioxygenase domain.

Protein cellular localization

Nucleus . Mitochondrion . Note: Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli (By similarity).

Background

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine.

Note

AntibodyPlus can customize ALKBH1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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