Rabbit polyclonal ALKBH3 antibody (A5808)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal ALKBH3 antibody (A5808)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ALKBH3 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ABH3 antibody, PCA1 antibody, DEPC1 antibody, DEPC-1 antibody
1700108H04Rik antibody|1810020C19Rik antibody|ABH3 antibody|AlkB homolog 3 antibody|alkB, alkylation repair homolog 3 (E. coli) antibody|ALKB3_HUMAN antibody|ALKBH3 antibody|Alkylated DNA repair protein alkB homolog 3 antibody|alkylation repair homolog 3 antibody|Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 antibody|DEPC 1 antibody|DEPC-1 antibody|DEPC1 antibody|EC 1.14.11. antibody|FLJ43614 antibody|mABH3 antibody|MGC118790 antibody|MGC118792 antibody|MGC118793 antibody|MGC134125 antibody|PCA1 antibody|Prostate cancer antigen 1 antibody|Prostate cancer antigen-1 antibody|RP23-375N21.4 antibody|Anti-ALKBH3 antibody (ab93174)

SCBT cat No: sc-376520|

Name

Rabbit polyclonal ALKBH3 antibody

Catalogue No.

A5808

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ALKBH3

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 33kDa/Observed: Refer to Figures

Formulation

ALKBH3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ALKBH3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ABH3 antibody, PCA1 antibody, DEPC1 antibody, DEPC-1 antibody

Database links

Human UniProt/Swiss-Prot:Q96Q83

Protein names

ABH3, PCA1, DEPC1, DEPC-1

Protein function

Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) . Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation . Has a strong preference for single-stranded DNA . Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 . Also acts on RNA . Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5′-untranslated regions (UTRs) and in the vicinity of start codons . Requires molecular oxygen, alpha-ketoglutarate and iron .

Protein tissue specificity

Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon.

Protein sequence and domain

Belongs to the alkB family.; Contains 1 Fe2OG dioxygenase domain.

Protein cellular localization

Nucleus . Cytoplasm . Note: Predominantly localizes to the nucleus.

Background

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002

Note

AntibodyPlus can customize ALKBH3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!