Rabbit polyclonal ALOX15B antibody (A6865)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ALOX15B antibody (A6865)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ALOX15B antibody.

Alternative names:

Check alternative names for the antibody

Expand

15-LOX-2 antibody
15 LO 2 antibody|15 LOX 2 antibody|15-lipoxygenase 2 antibody|15-LOX-2 antibody|15-LOX-B antibody|Alox15b antibody|Arachidonate 15 lipoxygenase second type antibody|Arachidonate 15 lipoxygenase type II antibody|Arachidonate 15-lipoxygenase B antibody|Arachidonate 15-lipoxygenase type II antibody|LX15B_HUMAN antibody|Anti-15 Lipoxygenase 2 antibody (ab23691)

SCBT cat No: sc-46048|sc-376871|sc-271290|sc-46049|sc-376795|sc-67142|sc-166387|sc-67143|

Name

Rabbit polyclonal ALOX15B antibody

Catalogue No.

A6865

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human ALOX15B

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 76kDa/Observed: Refer to figures

Formulation

ALOX15B antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ALOX15B antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

15-LOX-2 antibody

Database links

Human UniProt/Swiss-Prot:O15296

Protein names

15-LOX-2

Protein function

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.

Protein tissue specificity

Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.

Protein sequence and domain

The PLAT domain can bind calcium ions; this promotes association with membranes.Belongs to the lipoxygenase family.; Contains 1 lipoxygenase domain.; Contains 1 PLAT domain.

Protein cellular localization

Isoform A: Nucleus. Note: Other isoforms are excluded from the nucleus.; Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note: Predominantly cytosolic; becomes enriched at membranes upon calcium binding.

Background

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.

Research area

All research areas>Synthesis and Degradation>LO
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize ALOX15B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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