Rabbit polyclonal ALOXE3 antibody (A8245)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ALOXE3 antibody (A8245)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ALOXE3 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ARCI3 antibody, E-LOX antibody, eLOX3 antibody, eLOX-3 antibody
ALOXE3 antibody|Arachidonate lipoxygenase 3 antibody|e LOX 3 antibody|E LOX antibody|e-LOX-3 antibody|eLOX3 antibody|Epidermal lipoxygenase antibody|Epidermis-type lipoxygenase 3 antibody|Lipoxygenase 3 antibody|LOXE3_HUMAN antibody|Anti-ALOXE3 antibody (ab118470)

SCBT cat No: sc-133275|

Name

Rabbit polyclonal ALOXE3 antibody

Catalogue No.

A8245

Reactivity

Human

Immunogen

Recombinant protein of human ALOXE3

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 81kDa/Observed: Refer to figures

Formulation

ALOXE3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ALOXE3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ARCI3 antibody, E-LOX antibody, eLOX3 antibody, eLOX-3 antibody

Database links

Human UniProt/Swiss-Prot:Q9BYJ1

Protein names

ARCI3, E-LOX, eLOX3, eLOX-3

Protein function

Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.

Protein tissue specificity

Predominantly expressed in skin.

Protein sequence and domain

Belongs to the lipoxygenase family.; Contains 1 lipoxygenase domain.; Contains 1 PLAT domain.

Protein cellular localization

Cytoplasm .

Background

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize ALOXE3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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