Rabbit polyclonal AMBP antibody (A1846)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal AMBP antibody (A1846)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

A1M antibody, HCP antibody, ITI antibody, UTI antibody, EDC1 antibody, HI30 antibody, ITIL antibody, IATIL antibody, ITILC antibody
A1m antibody|C3 and PZP like alpha-2 macroglobulin domain containing protein 6 antibody|Complement component 3 and pregnancy zone protein like alpha 2 macroglobulin domain containing protein 6 antibody|CPAMD6 antibody|PZP antibody|Anti-Alpha 1 microglobulin antibody [BN11.10] (ab18513)

SCBT cat No: sc-135665|sc-109485|sc-292693|sc-73658|sc-67508|

Name

Rabbit polyclonal AMBP antibody

Catalogue No.

A1846

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human AMBP

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 39kDa/Observed: Refer to Figures

Formulation

AMBP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

AMBP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

A1M antibody, HCP antibody, ITI antibody, UTI antibody, EDC1 antibody, HI30 antibody, ITIL antibody, IATIL antibody, ITILC antibody

Database links

Human UniProt/Swiss-Prot:P02760

Protein names

A1M, HCP, ITI, UTI, EDC1, HI30, ITIL, IATIL, ITILC

Protein function

Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.; Trypstatin is a trypsin inhibitor.

Protein tissue specificity

Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.

Protein sequence and domain

In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.; Contains 2 BPTI/Kunitz inhibitor domains.

Protein post-translational modifications

The precursor is proteolytically processed into separately functioning proteins.; 3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region ‘Cys-352’.; Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.; N- and O-glycosylated. N-glycan heterogeneity at Asn-115: Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor). N-glycan at Asn-250: Hex5HexNAc4. O-linkage of the glycosaminoglycan, chondroitin sulfate, at Ser-215 allows cross-linking between the three polypeptide chains.

Protein cellular localization

Secreted.

Background

This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes.

Note

AntibodyPlus can customize AMBP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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