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Rabbit polyclonal AMOT antibody (A8075)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal AMOT antibody.
Check alternative names for the antibodyExpand
AMOT antibody|AMOT_HUMAN antibody|Angiomotin antibody|Angiomotin p130 isoform antibody|KIAA1071 antibody|Anti-Angiomotin antibody (ab85143)
SCBT cat No: sc-166924|sc-82491|sc-515262|sc-98803|sc-82493|
Rabbit polyclonal AMOT antibody
|Catalogue No.|| |
Recombinant protein of human AMOT
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 118kDa/Observed: Refer to figures
AMOT antibody was tube-contained.
AMOT antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
|Protein tissue specificity|| |
Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
|Protein sequence and domain|| |
The coiled coil domain interacts directly with the BAR domain of ARHGAP17.; The angiostatin binding domain (871-1005) allows the binding to angiostatin.Belongs to the angiomotin family.
|Protein post-translational modifications|| |
Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation.
|Protein cellular localization|| |
Cell junction, tight junction . Note: Localized on the cell surface. May act as a transmembrane protein.
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.
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|Product type|| |
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