Rabbit polyclonal AMOT antibody (A8075)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal AMOT antibody (A8075)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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AMOT antibody|AMOT_HUMAN antibody|Angiomotin antibody|Angiomotin p130 isoform antibody|KIAA1071 antibody|Anti-Angiomotin antibody (ab85143)

SCBT cat No: sc-166924|sc-82491|sc-515262|sc-98803|sc-82493|

Name

Rabbit polyclonal AMOT antibody

Catalogue No.

A8075

Reactivity

Human

Immunogen

Recombinant protein of human AMOT

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 118kDa/Observed: Refer to figures

Formulation

AMOT antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

AMOT antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q4VCS5

Protein function

Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.

Protein tissue specificity

Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.

Protein sequence and domain

The coiled coil domain interacts directly with the BAR domain of ARHGAP17.; The angiostatin binding domain (871-1005) allows the binding to angiostatin.Belongs to the angiomotin family.

Protein post-translational modifications

Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation.

Protein cellular localization

Cell junction, tight junction . Note: Localized on the cell surface. May act as a transmembrane protein.

Background

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research area

All research areas>Signaling Intermediates>Angiomotin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize AMOT antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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