Rabbit polyclonal ANGPT2 antibody (A0698)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ANGPT2 antibody (A0698)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ANGPT2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ANG-2 antibody, ANG2 antibody, AGPT2 antibody, Angiopoietin-2 antibody
AGPT 2 antibody|Agpt2 antibody|ANG 2 antibody|ANG-2 antibody|ANG2 antibody|Angiopoietin 2a antibody|Angiopoietin 2B antibody|Angiopoietin-2 antibody|Angiopoietin2 antibody|ANGP2_HUMAN antibody|ANGPT 2 antibody|Angpt2 antibody|Tie2 ligand antibody|Anti-Angiopoietin 2 antibody (ab8452)

SCBT cat No: sc-7015|sc-74403|sc-7017|sc-74402|sc-20718|sc-7016|

Name

Rabbit polyclonal ANGPT2 antibody

Catalogue No.

A0698

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ANGPT2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 57kDa/Observed: Refer to Figures

Formulation

ANGPT2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ANGPT2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ANG-2 antibody, ANG2 antibody, AGPT2 antibody, Angiopoietin-2 antibody

Database links

Human UniProt/Swiss-Prot:O15123

Protein names

ANG-2, ANG2, AGPT2, Angiopoietin-2

Protein function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Protein sequence and domain

The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.Contains 1 fibrinogen C-terminal domain.

Protein cellular localization

Secreted.

Background

Angiopoietins are a family of Tie receptor ligands. There are four angiopoietins discovered so far: angiopoietins 1, 2, 3 and 4 (Ang1, 2, 3, and 4) (1-3). Ang1 binds to the Tie-2 receptor and leads to its autophosphorylation and subsequent activation of downstream signaling pathways. It plays an important role in blood vessel formation, maturation and subsequent stabilization (1,4,5). Ang2 is an endothelium-specific growth factor that functions as an antagonist to Ang1, promotes vascular associated proinflammatory function, destabilizes quiescent endothelium, leads to vascular leakage and vascular destablization and remodeling (2,6,7). Ang2 is selectively expressed in many tumor tissues where, combined with other growth factors such as VEGF, it can promote vascular remodeling, angiogenesis and inflammation (7-9).

Research area

All research areas>Growth Factors and Hormones>Ang
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize ANGPT2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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