Rabbit polyclonal ANGPTL3 antibody (A0689)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ANGPTL3 antibody (A0689)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ANGPTL3 antibody,ANGPT5 antibody
ANG 5 antibody|Angiopoietin-5 antibody|ANGL3_HUMAN antibody|ANGPT5 antibody|ANGPTL3 antibody|ANL3 antibody|FHBL2 antibody|OTTHUMP00000010719 antibody|UNQ153/PRO179 antibody|Anti-ANGPTL3 antibody [EPR7319] (ab126718)

SCBT cat No: sc-365887|sc-68917|sc-68916|

Name

Rabbit polyclonal ANGPTL3 antibody

Catalogue No.

A0689

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ANGPTL3

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 54kDa/Observed: Refer to Figures

Formulation

ANGPTL3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ANGPTL3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ANGPTL3 antibody,ANGPT5 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y5C1

Protein names

ANGPTL3,ANGPT5

Protein function

Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism . Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1 . Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids . Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol . Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food; the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (By similarity). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR. May stimulate hypothalamic LPL activity (By similarity).; ANGPTL3(17-221): In vitro inhibits LPL activity; not effective on GPIHBP1-stabilized LPL.; Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration . Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling . May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS (By similarity).

Protein tissue specificity

Expressed principally in liver. Weakly expressed in kidney. Binds to adipocytes. Increased expression and colocalization with activated ITGB3 in glomeruli of patients with nephrotic syndrome showing effaced podocyte foot processes (at protein level).

Protein sequence and domain

The fibrinogen C-terminal domain is sufficient to mediate endothelial cell adhesion.Contains 1 fibrinogen C-terminal domain.

Protein post-translational modifications

O-glycosylated at Thr-226 by GALNT2; blocks processing and activation by proprotein convertases.; In part proteolytically cleaved by proprotein convertases; proposed to be involved in activation.

Protein cellular localization

Secreted . Cell projection, lamellipodium . Note: Colocalized with HSPG2 and activated ITGB3 on podocytes.

Background

Angiopoietin-like protein 3 (Angptl3) functions as a potent lipoprotein lipase inhibitor and is an important component of plasma triglyceride homeostasis. Angptl3 also plays a role in adipose formation and angiogenesis through its interaction with integrin alpha(v)beta(3). It is secreted by the liver and is functionally defined by the C-terminal fibrinogen (FBN)-like domain and an N-terminal coiled-coil domain. Angptl3 regulates circulating triglyceride levels during different nutritional states thereby mediating the feeding/fasting cycle. A deficiency of Angptl3 results in abnormally low lipid levels, and a repression of the protein may be protective against atherosclerosis. Angptl3 may also play an important role in hyperlipidemia in diabetes.

Research area

All research areas>Growth Factors and Hormones>Angptl
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize ANGPTL3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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