Rabbit polyclonal ANGPTL4 antibody (A2011)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ANGPTL4 antibody (A2011)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ANGPTL4 antibody.

Alternative names:

Check alternative names for the antibody

Expand

NL2 antibody, ARP4 antibody, FIAF antibody, HARP antibody, PGAR antibody, HFARP antibody, UNQ171 antibody, pp1158 antibody, ANGPTL2 antibody
Angiopoietin like 4 antibody|HFARP antibody|PGAR antibody|PSEC0166 antibody|TGQTL antibody|UNQ171 antibody|Weakly similar to angiopoietin 1 [H.sapiens] antibody|Anti-Angiopoietin-like 4 antibody (ab196746)

SCBT cat No: sc-32184|sc-32186|

Name

Rabbit polyclonal ANGPTL4 antibody

Catalogue No.

A2011

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human ANGPTL4

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

ANGPTL4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ANGPTL4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NL2 antibody, ARP4 antibody, FIAF antibody, HARP antibody, PGAR antibody, HFARP antibody, UNQ171 antibody, pp1158 antibody, ANGPTL2 antibody

Database links

Human UniProt/Swiss-Prot:Q9BY76

Protein names

NL2, ARP4, FIAF, HARP, PGAR, HFARP, UNQ171, pp1158, ANGPTL2

Protein function

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).

Protein tissue specificity

Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.

Protein sequence and domain

Contains 1 fibrinogen C-terminal domain.

Protein post-translational modifications

N-glycosylated.

Protein cellular localization

Secreted . Secreted, extracellular space, extracellular matrix . Note: The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity).

Background

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.

Research area

All research areas>Growth Factors and Hormones>Angptl
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize ANGPTL4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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