Rabbit polyclonal ANKS1B antibody (A7820)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ANKS1B antibody (A7820)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ANKS1B antibody.

Alternative names:

Check alternative names for the antibody

Expand

EB1 antibody, AIDA antibody, EB-1 antibody, ANKS2 antibody, AIDA-1 antibody, cajalin-2 antibody
AIDA antibody|AIDA-1 antibody|Amyloid-beta protein intracellular domain-associated protein 1 antibody|Anks1b antibody|ANKS2 antibody|Ankyrin repeat and sterile alpha motif domain containing 1B antibody|Ankyrin repeat and sterile alpha motif domain-containing protein 1B antibody|ANS1B_HUMAN antibody|Cajalin 2 antibody|E2A-PBX1-associated protein antibody|EB-1 antibody|EB1 antibody|MGC26087 antibody|Anti-ANKS1B antibody (ab192658)

SCBT cat No: sc-376610|

Name

Rabbit polyclonal ANKS1B antibody

Catalogue No.

A7820

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ANKS1B

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 138kDa/Observed: Refer to figures

Formulation

ANKS1B antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ANKS1B antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EB1 antibody, AIDA antibody, EB-1 antibody, ANKS2 antibody, AIDA-1 antibody, cajalin-2 antibody

Database links

Human UniProt/Swiss-Prot:Q7Z6G8

Protein names

EB1, AIDA, EB-1, ANKS2, AIDA-1, cajalin-2

Protein function

Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.

Protein tissue specificity

Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.

Protein sequence and domain

Contains 7 ANK repeats.; Contains 1 PID domain.; Contains 2 SAM (sterile alpha motif) domains.

Protein post-translational modifications

Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage.

Protein cellular localization

Cytoplasm .; Isoform 2: Nucleus.; Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note: The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity).; Isoform 4: Nucleus. Note: The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; Isoform 6: Nucleus.

Background

This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer’s disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene.

Note

AntibodyPlus can customize ANKS1B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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