Rabbit polyclonal ANPEP antibody (A5662)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ANPEP antibody (A5662)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

APN antibody, CD13 antibody, LAP1 antibody, P150 antibody, PEPN antibody, GP150 antibody
Alanyl (membrane) aminopeptidase antibody|Alanyl aminopeptidase antibody|Aminopeptidase M antibody|Aminopeptidase N antibody|AMPN_HUMAN antibody|ANPEP antibody|AP M antibody|AP N antibody|AP-M antibody|AP-N antibody|APN antibody|CD 13 antibody|CD13 antibody|CD13 antigen antibody|gp150 antibody|hAPN antibody|LAP 1 antibody|LAP1 antibody|Microsomal aminopeptidase antibody|Myeloid plasma membrane glycoprotein CD13 antibody|p150 antibody|PEPN antibody|Anti-CD13 antibody [EPR4058] (ab108310)

SCBT cat No: sc-136484|sc-13536|sc-166270|sc-65292|sc-53970|sc-15360|sc-166105|sc-6996|sc-18899|

Name

Rabbit polyclonal ANPEP antibody

Catalogue No.

A5662

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ANPEP

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 109kDa/Observed: Refer to Figures

Formulation

ANPEP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ANPEP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

APN antibody, CD13 antibody, LAP1 antibody, P150 antibody, PEPN antibody, GP150 antibody

Database links

Human UniProt/Swiss-Prot:P15144

Protein names

APN, CD13, LAP1, P150, PEPN, GP150

Protein function

Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.; (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E.

Protein tissue specificity

Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.

Protein sequence and domain

Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies).Belongs to the peptidase M1 family.

Protein post-translational modifications

Sulfated.; N- and O-glycosylated.; May undergo proteolysis and give rise to a soluble form.

Protein cellular localization

Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol . Note: A soluble form has also been detected.

Background

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.

Research area

All research areas>Lymphocyte Signaling>CD13
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize ANPEP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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