Rabbit Polyclonal Anti-Abin-2 antibody (STJ98808)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-Abin-2 antibody (STJ98808)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC-P, ELISA

Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|A20 binding inhibitor of NF kappaB activation 2 antibody|A20-binding inhibitor of NF-kappa-B activation 2 antibody|ABIN 2 antibody|ABIN-2 antibody|Fetal liver LKB1-interacting protein antibody|FLIP1 antibody|KLIP antibody|LKB1 interacting protein antibody|TNFAIP3 interacting protein 2 antibody|TNFAIP3-interacting protein 2 antibody|TNIP2 antibody|TNIP2_HUMAN antibody|Anti-TNIP2 antibody [EPR17434] (ab205925)
SCBT cat No: sc-50526|sc-271850|sc-32638|sc-32637|

Name

Anti-Abin-2 antibody

Catalogue No.

STJ98808

Reactivity

Human, Mouse, Rat

Specificity

Anti-Abin-2 antibody detects endogenous Abin-2.

Immunogen

Synthetic peptide from human protein at AA range: 61-110.

Host

Rabbit

Applications

IHC-P, ELISA

Recommended dilution

IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-Abin-2 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-Abin-2 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

A20 binding inhibitor of NF kappaB activation 2 antibody, A20-binding inhibitor of NF-kappa-B activation 2 antibody, ABIN 2 antibody, ABIN-2 antibody, Fetal liver LKB1-interacting protein antibody, FLIP1 antibody, KLIP antibody, LKB1 interacting protein antibody, TNFAIP3 interacting protein 2 antibody, TNFAIP3-interacting protein 2 antibody, TNIP2 antibody, TNIP2_HUMAN antibody

Database links

UniProt/Swiss-Prot:Q8NFZ5

Protein function

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. .

Protein tissue specificity

Ubiquitously expressed in all tissues examined. .

Protein sequence and domain

Contains 1 CCHC NOA-type zinc finger.

Protein post-translational modifications

In vitro phosphorylated by CHUK. .; Ubiquitinated; undergoes ‘Lys-48’-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination. .

Protein cellular localization

Cytoplasm . Nucleus .

Note

AntibodyPlus can customize Anti-Abin-2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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