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Rabbit Polyclonal Anti-Abin-2 antibody (STJ98808)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Abin-2 antibody.
Check alternative names for the antibodyExpand
|A20 binding inhibitor of NF kappaB activation 2 antibody|A20-binding inhibitor of NF-kappa-B activation 2 antibody|ABIN 2 antibody|ABIN-2 antibody|Fetal liver LKB1-interacting protein antibody|FLIP1 antibody|KLIP antibody|LKB1 interacting protein antibody|TNFAIP3 interacting protein 2 antibody|TNFAIP3-interacting protein 2 antibody|TNIP2 antibody|TNIP2_HUMAN antibody|Anti-TNIP2 antibody [EPR17434] (ab205925)
SCBT cat No: sc-50526|sc-271850|sc-32638|sc-32637|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Abin-2 antibody detects endogenous Abin-2.
Synthetic peptide from human protein at AA range: 61-110.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-Abin-2 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-Abin-2 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
A20 binding inhibitor of NF kappaB activation 2 antibody, A20-binding inhibitor of NF-kappa-B activation 2 antibody, ABIN 2 antibody, ABIN-2 antibody, Fetal liver LKB1-interacting protein antibody, FLIP1 antibody, KLIP antibody, LKB1 interacting protein antibody, TNFAIP3 interacting protein 2 antibody, TNFAIP3-interacting protein 2 antibody, TNIP2 antibody, TNIP2_HUMAN antibody
|Database links|| |
|Protein function|| |
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. .
|Protein tissue specificity|| |
Ubiquitously expressed in all tissues examined. .
|Protein sequence and domain|| |
Contains 1 CCHC NOA-type zinc finger.
|Protein post-translational modifications|| |
In vitro phosphorylated by CHUK. .; Ubiquitinated; undergoes ‘Lys-48’-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination. .
|Protein cellular localization|| |
Cytoplasm . Nucleus .
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St John’s Laboratory Ltd.
|Product type|| |
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