Rabbit Polyclonal Anti-ANG I antibody (STJ98719)

$99.00$319.00

Reactivity: Human
Applications: IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-ANG I antibody (STJ98719)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC-P, ELISA

Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Anti-ANG I antibody.

Alternative names:

Check alternative names for the antibody

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|ALS9 antibody|AMYOTROPHIC LATERAL SCLEROSIS antibody|ANG 1 antibody|ANG antibody|ANG I antibody|ANG1 antibody|ANGI antibody|ANGI_HUMAN antibody|Angiogenin antibody|Angiogenin ribonuclease RNase A family, 5 antibody|Epididymis luminal protein 168 antibody|HEL168 antibody|MGC22466 antibody|MGC71966 antibody|Ribonuclease 5 antibody|Ribonuclease RNase A Family 5 antibody|RNase 5 antibody|RNASE4 antibody|RNASE5 antibody|Anti-Angiogenin antibody [14017.7] (ab10600)
SCBT cat No: sc-1409|

Name

Anti-ANG I antibody

Catalogue No.

STJ98719

Reactivity

Human

Specificity

Anti-ANG I antibody detects endogenous ANG I.

Immunogen

Synthetic peptide from human protein at AA range: 20-60.

Host

Rabbit

Applications

IHC-P, ELISA

Recommended dilution

IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-ANG I antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-ANG I antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

ALS9 antibody, AMYOTROPHIC LATERAL SCLEROSIS antibody, ANG 1 antibody, ANG antibody, ANG I antibody, ANG1 antibody, ANGI antibody, ANGI_HUMAN antibody, Angiogenin antibody, Angiogenin ribonuclease RNase A family, 5 antibody, Epididymis luminal protein 168 antibody, HEL168 antibody, MGC22466 antibody, MGC71966 antibody, Ribonuclease 5 antibody, Ribonuclease RNase A Family 5 antibody, RNase 5 antibody, RNASE4 antibody, RNASE5 antibody

Database links

UniProt/Swiss-Prot:P03950

Protein function

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. .

Protein tissue specificity

Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. .

Involvement in disease

Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the pancreatic ribonuclease family.

Protein cellular localization

Cytoplasmic vesicle, secretory vesicle lumen . Secreted . Nucleus . Nucleus, nucleolus . Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708). .

Note

AntibodyPlus can customize Anti-ANG I antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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