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Rabbit Polyclonal Anti-ANG I antibody (STJ98719)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-ANG I antibody.
Check alternative names for the antibodyExpand
|ALS9 antibody|AMYOTROPHIC LATERAL SCLEROSIS antibody|ANG 1 antibody|ANG antibody|ANG I antibody|ANG1 antibody|ANGI antibody|ANGI_HUMAN antibody|Angiogenin antibody|Angiogenin ribonuclease RNase A family, 5 antibody|Epididymis luminal protein 168 antibody|HEL168 antibody|MGC22466 antibody|MGC71966 antibody|Ribonuclease 5 antibody|Ribonuclease RNase A Family 5 antibody|RNase 5 antibody|RNASE4 antibody|RNASE5 antibody|Anti-Angiogenin antibody [14017.7] (ab10600)
SCBT cat No: sc-1409|
Anti-ANG I antibody
|Catalogue No.|| |
Anti-ANG I antibody detects endogenous ANG I.
Synthetic peptide from human protein at AA range: 20-60.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-ANG I antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-ANG I antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ALS9 antibody, AMYOTROPHIC LATERAL SCLEROSIS antibody, ANG 1 antibody, ANG antibody, ANG I antibody, ANG1 antibody, ANGI antibody, ANGI_HUMAN antibody, Angiogenin antibody, Angiogenin ribonuclease RNase A family, 5 antibody, Epididymis luminal protein 168 antibody, HEL168 antibody, MGC22466 antibody, MGC71966 antibody, Ribonuclease 5 antibody, Ribonuclease RNase A Family 5 antibody, RNase 5 antibody, RNASE4 antibody, RNASE5 antibody
|Database links|| |
|Protein function|| |
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. .
|Protein tissue specificity|| |
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. .
|Involvement in disease|| |
Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the pancreatic ribonuclease family.
|Protein cellular localization|| |
Cytoplasmic vesicle, secretory vesicle lumen . Secreted . Nucleus . Nucleus, nucleolus . Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708). .
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St John’s Laboratory Ltd.
|Product type|| |
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