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Rabbit Polyclonal Anti-ATG13 antibody (STJ98934)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-ATG13 antibody.
Check alternative names for the antibodyExpand
|ATG13 antibody|FLJ20698 antibody|KIAA0652 antibody|OTTHUMP00000233321 antibody|OTTHUMP00000233322 antibody|OTTHUMP00000233323 antibody|OTTHUMP00000233324 antibody|OTTHUMP00000233325 antibody|OTTHUMP00000233326 antibody|Anti-KIAA0652 antibody [EPR19601] (ab201467)
SCBT cat No: sc-240548|sc-240546|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-ATG13 antibody detects endogenous ATG13 protein.
Recombinant Protein of ATG13.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-ATG13 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-ATG13 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ATG13 antibody, FLJ20698 antibody, KIAA0652 antibody, OTTHUMP00000233321 antibody, OTTHUMP00000233322 antibody, OTTHUMP00000233323 antibody, OTTHUMP00000233324 antibody, OTTHUMP00000233325 antibody, OTTHUMP00000233326 antibody
|Database links|| |
|Protein function|| |
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. .
|Protein sequence and domain|| |
Belongs to the ATG13 family. Metazoan subfamily. The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and MAP1LC3A.
|Protein post-translational modifications|| |
Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria. .
|Protein cellular localization|| |
Cytoplasm, cytosol . Preautophagosomal structure . Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. .
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St John’s Laboratory Ltd.
|Product type|| |
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