Rabbit Polyclonal Anti-ATG13 antibody (STJ98934)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-ATG13 antibody (STJ98934)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|ATG13 antibody|FLJ20698 antibody|KIAA0652 antibody|OTTHUMP00000233321 antibody|OTTHUMP00000233322 antibody|OTTHUMP00000233323 antibody|OTTHUMP00000233324 antibody|OTTHUMP00000233325 antibody|OTTHUMP00000233326 antibody|Anti-KIAA0652 antibody [EPR19601] (ab201467)
SCBT cat No: sc-240548|sc-240546|

Name

Anti-ATG13 antibody

Catalogue No.

STJ98934

Reactivity

Human, Mouse, Rat

Specificity

Anti-ATG13 antibody detects endogenous ATG13 protein.

Immunogen

Recombinant Protein of ATG13.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

57kDa

Formulation

Anti-ATG13 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-ATG13 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

ATG13 antibody, FLJ20698 antibody, KIAA0652 antibody, OTTHUMP00000233321 antibody, OTTHUMP00000233322 antibody, OTTHUMP00000233323 antibody, OTTHUMP00000233324 antibody, OTTHUMP00000233325 antibody, OTTHUMP00000233326 antibody

Database links

UniProt/Swiss-Prot:O75143

Protein function

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. .

Protein sequence and domain

Belongs to the ATG13 family. Metazoan subfamily. The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and MAP1LC3A.

Protein post-translational modifications

Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria. .

Protein cellular localization

Cytoplasm, cytosol . Preautophagosomal structure . Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. .

Research area

All research areas>Synthesis and Degradation>Atg
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize Anti-ATG13 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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