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Rabbit Polyclonal Anti-ATG5 antibody (STJ98931)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-ATG5 antibody.
Check alternative names for the antibodyExpand
|APG 5 antibody|ATG5_HUMAN antibody|Autophagy protein 5 antibody|hAPG5 antibody|Homolog of S Cerevisiae autophagy 5 antibody|OTTHUMP00000040507 antibody|Anti-APG5L/ATG5 antibody [EPR1755(2)] (ab108327)
SCBT cat No: sc-133158|sc-8667|sc-515347|sc-33210|sc-8666|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-ATG5 antibody detects endogenous ATG5 protein.
Recombinant Protein of ATG5.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-ATG5 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-ATG5 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
APG 5 antibody, ATG5_HUMAN antibody, Autophagy protein 5 antibody, hAPG5 antibody, Homolog of S Cerevisiae autophagy 5 antibody, OTTHUMP00000040507 antibody
|Database links|| |
|Protein function|| |
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.; May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
|Protein tissue specificity|| |
Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
|Protein sequence and domain|| |
Belongs to the ATG5 family.
|Protein post-translational modifications|| |
Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.; Acetylated by EP300. .
|Protein cellular localization|| |
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .
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St John’s Laboratory Ltd.
|Product type|| |
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