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Rabbit Polyclonal Anti-ATG7 antibody (STJ98932)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-ATG7 antibody.
Check alternative names for the antibodyExpand
|1810013K23Rik antibody|DKFZp434N0735 antibody|GSA 7 antibody|GSA7 antibody|hAGP7 antibody|Ubiquitin activating enzyme E1 like protein antibody|Ubiquitin-activating enzyme E1-like protein antibody|Ubiquitin-like modifier-activating enzyme ATG7 antibody|Anti-Apg7 antibody [EP1759Y] (ab52472)
SCBT cat No: sc-376212|sc-33211|sc-12497|sc-8668|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-ATG7 antibody detects endogenous ATG7 protein.
Recombinant Protein of ATG7.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-ATG7 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-ATG7 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
1810013K23Rik antibody, DKFZp434N0735 antibody, GSA 7 antibody, GSA7 antibody, hAGP7 antibody, Ubiquitin activating enzyme E1 like protein antibody, Ubiquitin-activating enzyme E1-like protein antibody, Ubiquitin-like modifier-activating enzyme ATG7 antibody
|Database links|| |
|Protein function|| |
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. .
|Protein tissue specificity|| |
Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. .
|Protein sequence and domain|| |
Belongs to the ATG7 family. The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12. ; The N-terminal FAP motif (residues 15 to 17) is essential for the formation of the ATG89-PE and ATG5-ATG12 conjugates.
|Protein post-translational modifications|| |
Acetylated by EP300. .
|Protein cellular localization|| |
Cytoplasm . Preautophagosomal structure . Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .
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St John’s Laboratory Ltd.
|Product type|| |
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