Rabbit Polyclonal Anti-BMP-1 antibody (STJ98798)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-BMP-1 antibody (STJ98798)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC-P, ELISA

Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

|BMP 1 antibody|Bone morphogenetic protein 1 antibody|Mammalian tolloid protein antibody|mTld antibody|OI13 antibody|PCOLC antibody|PCP antibody|PCP2 antibody|Procollagen C endopeptidase antibody|Procollagen C proteinase antibody|TLD antibody|Tolloid, Drosophila, homolog of antibody|Anti-BMP1 antibody (ab118520)
SCBT cat No: sc-27324|sc-33200|sc-16962|

Name

Anti-BMP-1 antibody

Catalogue No.

STJ98798

Reactivity

Human, Mouse, Rat

Specificity

Anti-BMP-1 antibody detects endogenous BMP-1.

Immunogen

Synthetic peptide from human protein at AA range: 131-180.

Host

Rabbit

Applications

IHC-P, ELISA

Recommended dilution

IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-BMP-1 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-BMP-1 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

BMP 1 antibody, Bone morphogenetic protein 1 antibody, Mammalian tolloid protein antibody, mTld antibody, OI13 antibody, PCOLC antibody, PCP antibody, PCP2 antibody, Procollagen C endopeptidase antibody, Procollagen C proteinase antibody, TLD antibody, Tolloid, Drosophila, homolog of antibody

Database links

UniProt/Swiss-Prot:P13497

Protein function

Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.

Protein tissue specificity

Ubiquitous.

Involvement in disease

Osteogenesis imperfecta 13 (OI13) [MIM:614856]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both upper and lower limbs. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase M12A family. ; Contains 5 CUB domains. ; Contains 2 EGF-like domains.

Protein post-translational modifications

Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion. .

Protein cellular localization

Golgi apparatus, trans-Golgi network . Secreted, extracellular space, extracellular matrix . Note=Co-localizes with POSTN in the Golgi. .

Note

AntibodyPlus can customize Anti-BMP-1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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