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Rabbit Polyclonal Anti-BMP-1 antibody (STJ98798)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-BMP-1 antibody.
Check alternative names for the antibodyExpand
|BMP 1 antibody|Bone morphogenetic protein 1 antibody|Mammalian tolloid protein antibody|mTld antibody|OI13 antibody|PCOLC antibody|PCP antibody|PCP2 antibody|Procollagen C endopeptidase antibody|Procollagen C proteinase antibody|TLD antibody|Tolloid, Drosophila, homolog of antibody|Anti-BMP1 antibody (ab118520)
SCBT cat No: sc-27324|sc-33200|sc-16962|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-BMP-1 antibody detects endogenous BMP-1.
Synthetic peptide from human protein at AA range: 131-180.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-BMP-1 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-BMP-1 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
BMP 1 antibody, Bone morphogenetic protein 1 antibody, Mammalian tolloid protein antibody, mTld antibody, OI13 antibody, PCOLC antibody, PCP antibody, PCP2 antibody, Procollagen C endopeptidase antibody, Procollagen C proteinase antibody, TLD antibody, Tolloid, Drosophila, homolog of antibody
|Database links|| |
|Protein function|| |
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.
|Protein tissue specificity|| |
|Involvement in disease|| |
Osteogenesis imperfecta 13 (OI13) [MIM:614856]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both upper and lower limbs. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase M12A family. ; Contains 5 CUB domains. ; Contains 2 EGF-like domains.
|Protein post-translational modifications|| |
Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion. .
|Protein cellular localization|| |
Golgi apparatus, trans-Golgi network . Secreted, extracellular space, extracellular matrix . Note=Co-localizes with POSTN in the Golgi. .
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St John’s Laboratory Ltd.
|Product type|| |
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