Rabbit Polyclonal Anti-Caspase-3 antibody (STJ98967)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-Caspase-3 antibody (STJ98967)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|Apopain antibody|CASP 3 antibody|CASP-3 antibody|CASP3 antibody|CASP3_HUMAN antibody|Caspase 3 antibody|Caspase-3 subunit p12 antibody|CPP 32 antibody|CPP-32 antibody|CPP32B antibody|Cysteine protease CPP32 antibody|PARP cleavage protease antibody|Protein Yama antibody|SCA-1 antibody|SCA1 antibody|SREBP cleavage activity 1 antibody|Yama antibody|Anti-active Caspase-3 (Asp175) antibody (ab2302)
SCBT cat No: sc-56053|sc-70497|sc-65496|sc-56046|sc-70498|sc-65497|sc-136219|sc-56050|sc-56051|sc-56052|sc-7272|sc-7148|sc-1225|sc-271759|sc-1224|sc-271028|sc-373730|sc-166589|sc-98785|sc-22139|sc-22140|sc-1226|sc-56056|sc-1229|

Name

Anti-Caspase-3 antibody

Catalogue No.

STJ98967

Reactivity

Human, Mouse, Rat

Specificity

Anti-Caspase-3 antibody detects endogenous Caspase-3.

Immunogen

Synthetic peptide from human protein at AA range: 134-205.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-Caspase-3 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Caspase-3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Apopain antibody, CASP 3 antibody, CASP-3 antibody, CASP3 antibody, CASP3_HUMAN antibody, Caspase 3 antibody, Caspase-3 subunit p12 antibody, CPP 32 antibody, CPP-32 antibody, CPP32B antibody, Cysteine protease CPP32 antibody, PARP cleavage protease antibody, Protein Yama antibody, SCA-1 antibody, SCA1 antibody, SREBP cleavage activity 1 antibody, Yama antibody

Database links

UniProt/Swiss-Prot:P42574

Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ‘216-Asp-, -Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. .

Protein tissue specificity

Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

Protein sequence and domain

Belongs to the peptidase C14A family.

Protein post-translational modifications

Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.; S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol. .

Protein cellular localization

Cytoplasm.

Research area

All research areas>Tumor Suppressor/Apoptosis>Caspase
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Anti-Caspase-3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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