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Rabbit Polyclonal Anti-Caspase-3 antibody (STJ98967)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Caspase-3 antibody.
Check alternative names for the antibodyExpand
|Apopain antibody|CASP 3 antibody|CASP-3 antibody|CASP3 antibody|CASP3_HUMAN antibody|Caspase 3 antibody|Caspase-3 subunit p12 antibody|CPP 32 antibody|CPP-32 antibody|CPP32B antibody|Cysteine protease CPP32 antibody|PARP cleavage protease antibody|Protein Yama antibody|SCA-1 antibody|SCA1 antibody|SREBP cleavage activity 1 antibody|Yama antibody|Anti-active Caspase-3 (Asp175) antibody (ab2302)
SCBT cat No: sc-56053|sc-70497|sc-65496|sc-56046|sc-70498|sc-65497|sc-136219|sc-56050|sc-56051|sc-56052|sc-7272|sc-7148|sc-1225|sc-271759|sc-1224|sc-271028|sc-373730|sc-166589|sc-98785|sc-22139|sc-22140|sc-1226|sc-56056|sc-1229|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Caspase-3 antibody detects endogenous Caspase-3.
Synthetic peptide from human protein at AA range: 134-205.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
Anti-Caspase-3 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Caspase-3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Apopain antibody, CASP 3 antibody, CASP-3 antibody, CASP3 antibody, CASP3_HUMAN antibody, Caspase 3 antibody, Caspase-3 subunit p12 antibody, CPP 32 antibody, CPP-32 antibody, CPP32B antibody, Cysteine protease CPP32 antibody, PARP cleavage protease antibody, Protein Yama antibody, SCA-1 antibody, SCA1 antibody, SREBP cleavage activity 1 antibody, Yama antibody
|Database links|| |
|Protein function|| |
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-, -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. .
|Protein tissue specificity|| |
Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
|Protein sequence and domain|| |
Belongs to the peptidase C14A family.
|Protein post-translational modifications|| |
Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.; S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol. .
|Protein cellular localization|| |
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/Caspase/">Caspase</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"> (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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