Rabbit Polyclonal Anti-Caspase-3 antibody (STJ98967)


Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-Caspase-3 antibody (STJ98967)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


|Apopain antibody|CASP 3 antibody|CASP-3 antibody|CASP3 antibody|CASP3_HUMAN antibody|Caspase 3 antibody|Caspase-3 subunit p12 antibody|CPP 32 antibody|CPP-32 antibody|CPP32B antibody|Cysteine protease CPP32 antibody|PARP cleavage protease antibody|Protein Yama antibody|SCA-1 antibody|SCA1 antibody|SREBP cleavage activity 1 antibody|Yama antibody|Anti-active Caspase-3 (Asp175) antibody (ab2302)
SCBT cat No: sc-56053|sc-70497|sc-65496|sc-56046|sc-70498|sc-65497|sc-136219|sc-56050|sc-56051|sc-56052|sc-7272|sc-7148|sc-1225|sc-271759|sc-1224|sc-271028|sc-373730|sc-166589|sc-98785|sc-22139|sc-22140|sc-1226|sc-56056|sc-1229|


Anti-Caspase-3 antibody

Catalogue No.



Human, Mouse, Rat


Anti-Caspase-3 antibody detects endogenous Caspase-3.


Synthetic peptide from human protein at AA range: 134-205.












Anti-Caspase-3 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


Anti-Caspase-3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Apopain antibody, CASP 3 antibody, CASP-3 antibody, CASP3 antibody, CASP3_HUMAN antibody, Caspase 3 antibody, Caspase-3 subunit p12 antibody, CPP 32 antibody, CPP-32 antibody, CPP32B antibody, Cysteine protease CPP32 antibody, PARP cleavage protease antibody, Protein Yama antibody, SCA-1 antibody, SCA1 antibody, SREBP cleavage activity 1 antibody, Yama antibody

Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-, -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. .

Protein tissue specificity

Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

Protein sequence and domain

Belongs to the peptidase C14A family.

Protein post-translational modifications

Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.; S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol. .

Protein cellular localization


Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/Caspase/">Caspase</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"&gt; (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>


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St John’s Laboratory Ltd.

Product type

Primary antibody


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