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Rabbit Polyclonal Anti-CD152 antibody (STJ98747)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|ALPS5 antibody|CD 152 antibody|CD antibody|CD152 antibody|CD152 antigen antibody|CD152 isoform antibody|Celiac disease 3 antibody|CELIAC3 antibody|CTLA 4 antibody|CTLA-4 antibody|CTLA4 antibody|CTLA4_HUMAN antibody|Cytotoxic T cell associated 4 antibody|Cytotoxic T lymphocyte antigen 4 antibody|Cytotoxic T lymphocyte associated 4 antibody|Cytotoxic T lymphocyte associated 4, soluble isoform, included antibody|Cytotoxic T lymphocyte associated antigen 4 antibody|Cytotoxic T lymphocyte associated antigen 4 short spliced form antibody|Cytotoxic T lymphocyte associated protein 4 antibody|Cytotoxic T lymphocyte associated serine esterase 4 antibody|Cytotoxic T lymphocyte protein 4 antibody|Cytotoxic T-lymphocyte protein 4 antibody|Cytotoxic T-lymphocyte-associated antigen 4 antibody|GRD4 antibody|GSE antibody|ICOS antibody|IDDM12 antibody|insulin-dependent diabetes mellitus 12 antibody|Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 antibody|OTTHUMP00000216623 antibody|Anti-CTLA4 antibody [EPR1476] (ab134090)
SCBT cat No: sc-1628|sc-376016|sc-9094|
|Catalogue No.|| |
Anti-CD152 antibody detects endogenous CD152.
Synthetic peptide from human protein at AA range: 41-90.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-CD152 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-CD152 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ALPS5 antibody, CD 152 antibody, CD antibody, CD152 antibody, CD152 antigen antibody, CD152 isoform antibody, Celiac disease 3 antibody, CELIAC3 antibody, CTLA 4 antibody, CTLA-4 antibody, CTLA4 antibody, CTLA4_HUMAN antibody, Cytotoxic T cell associated 4 antibody, Cytotoxic T lymphocyte antigen 4 antibody, Cytotoxic T lymphocyte associated 4 antibody, Cytotoxic T lymphocyte associated 4, soluble isoform, included antibody, Cytotoxic T lymphocyte associated antigen 4 antibody, Cytotoxic T lymphocyte associated antigen 4 short spliced form antibody, Cytotoxic T lymphocyte associated protein 4 antibody, Cytotoxic T lymphocyte associated serine esterase 4 antibody, Cytotoxic T lymphocyte protein 4 antibody, Cytotoxic T-lymphocyte protein 4 antibody, Cytotoxic T-lymphocyte-associated antigen 4 antibody, GRD4 antibody, GSE antibody, ICOS antibody, IDDM12 antibody, insulin-dependent diabetes mellitus 12 antibody, Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 antibody, OTTHUMP00000216623 antibody
|Database links|| |
|Protein function|| |
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. .
|Protein tissue specificity|| |
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. .
|Involvement in disease|| |
Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Note=Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. .; Diabetes mellitus, insulin-dependent, 12 (IDDM12) [MIM:601388]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Celiac disease 3 (CELIAC3) [MIM:609755]: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Autoimmune lymphoproliferative syndrome 5 (ALPS5) [MIM:616100]: An autosomal dominant primary immunodeficiency characterized by severe autoimmunity, infiltration of non-lymphoid organs, such as the intestine, lungs and brain, by hyperactive T cells and B cells, autoimmune cytopenias, and hypogammaglobulinemia in early childhood. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
|Protein post-translational modifications|| |
N-glycosylation is important for dimerization. .; Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. .
|Protein cellular localization|| |
Cell membrane ; Single-pass type I membrane protein . Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
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St John’s Laboratory Ltd.
|Product type|| |
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