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Rabbit Polyclonal Anti-CD24 antibody (STJ98990)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SCBT cat No:
|Catalogue No.|| |
Anti-CD24 antibody detects endogenous CD24 .
Synthetic peptide from human protein at AA range: 30-60.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
Anti-CD24 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-CD24 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Database links|| |
|Protein function|| |
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. .
|Protein tissue specificity|| |
B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. .
|Involvement in disease|| |
Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. . Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the CD24 family.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Cell membrane; Lipid-anchor, GPI-anchor.
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St John’s Laboratory Ltd.
|Product type|| |
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