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Rabbit Polyclonal Anti-Cdk6 antibody (STJ98721)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC-P, ELISA
Recommended dilution: WB 1:500-2000; IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|CDK 6 antibody|CDK6 antibody|CDK6_HUMAN antibody|Cell division protein kinase 6 antibody|Crk 2 antibody|Crk2 antibody|Cyclin dependent kinase 6 antibody|Cyclin-dependent kinase 6 antibody|MGC59692 antibody|p40 antibody|PLSTIRE antibody|Serine/threonine protein kinase PLSTIRE antibody|Serine/threonine-protein kinase PLSTIRE antibody|STQTL11 antibody|Anti-Cdk6 antibody [EPR4515] (ab124821) KO Validated
SCBT cat No: sc-7961|sc-177|sc-53638|sc-56282|sc-390493|sc-271364|sc-7181|sc-7180|sc-32501|sc-56362|sc-136386|
|Catalogue No.|| |
Anti-Cdk6 antibody detects endogenous Cdk6.
Synthetic peptide from human protein at AA range: 280-325.
WB, IHC-P, ELISA
|Recommended dilution|| |
WB 1:500-2000; IHC-P 1:50-300; ELISA 1:5000-20000
|Molecular weight|| |
Anti-Cdk6 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-Cdk6 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CDK 6 antibody, CDK6 antibody, CDK6_HUMAN antibody, Cell division protein kinase 6 antibody, Crk 2 antibody, Crk2 antibody, Cyclin dependent kinase 6 antibody, Cyclin-dependent kinase 6 antibody, MGC59692 antibody, p40 antibody, PLSTIRE antibody, Serine/threonine protein kinase PLSTIRE antibody, Serine/threonine-protein kinase PLSTIRE antibody, STQTL11 antibody
|Database links|| |
|Protein function|| |
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). .
|Protein tissue specificity|| |
Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. .
|Involvement in disease|| |
Microcephaly 12, primary, autosomal recessive (MCPH12) [MIM:616080]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. ; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity. .
|Protein cellular localization|| |
Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). .
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St John’s Laboratory Ltd.
|Product type|| |
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