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Rabbit Polyclonal Anti-COL12A1 antibody (STJ98958)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-COL12A1 antibody.
Check alternative names for the antibodyExpand
|BA209D8.1 antibody|COCA1 antibody|COL12A1 antibody|COL12A1L antibody|Collagen alpha-1(XII) chain antibody|collagen type XII proteoglycan antibody|collagen, type XII, alpha 1 antibody|DJ234P15.1 antibody|Anti-COL12A1 antibody (ab196619)
SCBT cat No: sc-166020|sc-68449|sc-68862|
|Catalogue No.|| |
Anti-COL12A1 antibody detects endogenous COL12A1.
Synthetic peptide from human protein at AA range: 1993-2064.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
Anti-COL12A1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-COL12A1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
BA209D8.1 antibody, COCA1 antibody, COL12A1 antibody, COL12A1L antibody, Collagen alpha-1(XII) chain antibody, collagen type XII proteoglycan antibody, collagen, type XII, alpha 1 antibody, DJ234P15.1 antibody
|Database links|| |
|Protein function|| |
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. .
|Protein tissue specificity|| |
Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, kidney and a squamous cell carcinoma cell line. Isoform 1 is also present in the corneal epithelial Bowman’s membrane (BM) and the interfibrillar matrix of the corneal stroma, but it is not detected in the limbal BM. .
|Involvement in disease|| |
Ullrich congenital muscular dystrophy 2 (UCMD2) [MIM:616470]: A form of Ullrich muscular dystrophy, a congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Bethlem myopathy 2 (BTHLM2) [MIM:616471]: A form of Bethlem myopathy, a benign proximal myopathy characterized by early childhood onset and joint contractures most frequently affecting the elbows and ankles. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. ; Contains 4 collagen-like domains. ; Contains 18 fibronectin type-III domains. ; Contains 1 laminin G-like domain. ; Contains 4 VWFA domains.
|Protein post-translational modifications|| |
The triple-helical tail is stabilized by disulfide bonds at each end. .; Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. .; Isoform 1 O-glycosylation; glycosaminoglycan of chondroitin-sulfate type. .
|Protein cellular localization|| |
Secreted, extracellular space, extracellular matrix .
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St John’s Laboratory Ltd.
|Product type|| |
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