Rabbit Polyclonal Anti-COL8A2 antibody (STJ99330)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-COL8A2 antibody (STJ99330)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|AI429819 antibody|Collagen, type VIII, alpha 2 antibody|FECD antibody|FECD1 antibody|FLJ00201 antibody|MGC116970 antibody|MGC116972 antibody|MGC90765 antibody|PPCD antibody|PPCD2 antibody|RP23-113P22.2 antibody|RP4-665N4.3 antibody|Anti-COL8A2 antibody (ab112110)
SCBT cat No: sc-293350|sc-82841|sc-134947|sc-82843|sc-82844|

Size

20ul trial, 50ul, 100ul, 200ul

Name

Anti-COL8A2 antibody

Catalogue No.

STJ99330

Reactivity

Human, Mouse, Rat

Specificity

Anti-COL8A2 antibody detects endogenous levels of COL8A2.

Immunogen

Synthesized peptide derived from human COL8A2. at AA range: 611-660.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

80kDa

Formulation

Anti-COL8A2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-COL8A2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

AI429819 antibody, Collagen, type VIII, alpha 2 antibody, FECD antibody, FECD1 antibody, FLJ00201 antibody, MGC116970 antibody, MGC116972 antibody, MGC90765 antibody, PPCD antibody, PPCD2 antibody, RP23-113P22.2 antibody, RP4-665N4.3 antibody

Database links

UniProt/Swiss-Prot:P25067

Protein function

Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). .

Protein tissue specificity

Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet’s membrane. .

Involvement in disease

Corneal dystrophy, Fuchs endothelial, 1 (FECD1) [MIM:136800]: A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Corneal dystrophy, posterior polymorphous, 2 (PPCD2) [MIM:609140]: A rare mild subtype of posterior corneal dystrophy characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Contains 1 C1q domain.

Protein post-translational modifications

Proteolytically cleaved by neutrophil elastase, in vitro. .; Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Protein cellular localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Note

AntibodyPlus can customize Anti-COL8A2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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